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Single-nuclei UPR profiling by flow cytometry reveals bortezomib resistance mechanisms in multiple myeloma.

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Title: Single-nuclei UPR profiling by flow cytometry reveals bortezomib resistance mechanisms in multiple myeloma.
Authors: Gigan JP; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Garcia-Gonzalez P; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Pilotti A; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Galliot L; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Reynaud A; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Ghaffar Y; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Flores-Santibáñez F; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Ghafoori S; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Seillier E; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Lavignolle-Heguy R; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Barros D; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Bret C; Institute for Research in Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Fichaux S; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Combes A; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine Division of Gastroenterology, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLab, University of California San Francisco, San Francisco, CA, USA.; UCSF ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA., Bani A; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Rua R; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Gatti E; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Nal-Rogier B; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France., Rocchi S; Université Côte d'Azur, INSERM U1065, C3M, Nice, France., Moreaux J; CNRS UMR 9002-CNRS-UM - Institute of Human Genetics, Montpellier, France., Pierre P; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France. pierre@ciml.univ-mrs.fr.; Institute for Research in Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. pierre@ciml.univ-mrs.fr.; Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. pierre@ciml.univ-mrs.fr., Argüello RJ; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France. rafael.arguello@cnrs.fr.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jun 29. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Single-nuclei UPR profiling by flow cytometry reveals bortezomib resistance mechanisms in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Gigan+JP%22">Gigan JP</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Garcia-Gonzalez+P%22">Garcia-Gonzalez P</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Pilotti+A%22">Pilotti A</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Galliot+L%22">Galliot L</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Reynaud+A%22">Reynaud A</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Ghaffar+Y%22">Ghaffar Y</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Flores-Santibáñez+F%22">Flores-Santibáñez F</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Ghafoori+S%22">Ghafoori S</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Seillier+E%22">Seillier E</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Lavignolle-Heguy+R%22">Lavignolle-Heguy R</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Barros+D%22">Barros D</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bret+C%22">Bret C</searchLink>; Institute for Research in Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Fichaux+S%22">Fichaux S</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Combes+A%22">Combes A</searchLink>; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine Division of Gastroenterology, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLab, University of California San Francisco, San Francisco, CA, USA.; UCSF ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bani+A%22">Bani A</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Rua+R%22">Rua R</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Gatti+E%22">Gatti E</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Nal-Rogier+B%22">Nal-Rogier B</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Rocchi+S%22">Rocchi S</searchLink>; Université Côte d'Azur, INSERM U1065, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Moreaux+J%22">Moreaux J</searchLink>; CNRS UMR 9002-CNRS-UM - Institute of Human Genetics, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Pierre+P%22">Pierre P</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France. pierre@ciml.univ-mrs.fr.; Institute for Research in Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. pierre@ciml.univ-mrs.fr.; Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. pierre@ciml.univ-mrs.fr.<br /><searchLink fieldCode="AU" term="%22Argüello+RJ%22">Argüello RJ</searchLink>; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France. rafael.arguello@cnrs.fr.
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