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Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.

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Title: Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.
Authors: Neo SY; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. neo_shi_yong@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore. neo_shi_yong@a-star.edu.sg., Mei Y; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore., Chong J; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Lee KY; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Lim JY; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Rajapakse MP; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Shuen TWH; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore., Zhao J; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore., Tong L; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.; Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Kajiji T; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Cheong HS; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore., Toh C; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore., Neo ZW; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Republic of Singapore., Chong LY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Tang WL; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Ang N; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Tay A; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Chen X; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden., Johan H; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska university hospital, Stockholm, Sweden., Howland SW; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Yeong JPS; Duke-NUS Medical School, Singapore, Republic of Singapore.; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Republic of Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Microbiology, Singapore General Hospital, Singapore, Republic of Singapore., Biswas SK; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research and Clinical Division of Infectious Diseases, Medical University of Graz, Graz, Austria., Lim E; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore., Yu H; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; CAMP, Singapore-MIT Alliance for Research and Technology, Singapore, Republic of Singapore.; Mechanobiology Institute, National University of Singapore, Singapore, Republic of Singapore., Xu S; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Toh HC; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore., Liu H; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore., Lam KP; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. lam_kong_peng@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore. lam_kong_peng@a-star.edu.sg.; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. lam_kong_peng@a-star.edu.sg.
Source: Nature communications [Nat Commun] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Neo+SY%22">Neo SY</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. neo_shi_yong@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore. neo_shi_yong@a-star.edu.sg.<br /><searchLink fieldCode="AU" term="%22Mei+Y%22">Mei Y</searchLink>; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+J%22">Chong J</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+KY%22">Lee KY</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+JY%22">Lim JY</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Rajapakse+MP%22">Rajapakse MP</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Shuen+TWH%22">Shuen TWH</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tong+L%22">Tong L</searchLink>; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.; Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Kajiji+T%22">Kajiji T</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Cheong+HS%22">Cheong HS</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Toh+C%22">Toh C</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Neo+ZW%22">Neo ZW</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+LY%22">Chong LY</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tang+WL%22">Tang WL</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Ang+N%22">Ang N</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+A%22">Tay A</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Johan+H%22">Johan H</searchLink>; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska university hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Howland+SW%22">Howland SW</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Yeong+JPS%22">Yeong JPS</searchLink>; Duke-NUS Medical School, Singapore, Republic of Singapore.; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Republic of Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Microbiology, Singapore General Hospital, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Biswas+SK%22">Biswas SK</searchLink>; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research and Clinical Division of Infectious Diseases, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Lim+E%22">Lim E</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; CAMP, Singapore-MIT Alliance for Research and Technology, Singapore, Republic of Singapore.; Mechanobiology Institute, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Toh+HC%22">Toh HC</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lam+KP%22">Lam KP</searchLink>; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. lam_kong_peng@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore. lam_kong_peng@a-star.edu.sg.; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. lam_kong_peng@a-star.edu.sg.
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