Distinctive Reactivity to the C-terminal Epitope of BP180 Characterizes Immune Checkpoint Inhibitor-associated Bullous Pemphigoid, and an ELISA Based on the BP180 Ectodomain Enables Prompt Diagnosis in a Subset of Patients.

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Title: Distinctive Reactivity to the C-terminal Epitope of BP180 Characterizes Immune Checkpoint Inhibitor-associated Bullous Pemphigoid, and an ELISA Based on the BP180 Ectodomain Enables Prompt Diagnosis in a Subset of Patients.
Authors: Pira A; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Merli M; Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; Dermatology Clinic, Department of Medical Sciences, A.O. Ordine Mauriziano, Turin, Italy., Mariotti F; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy. f.mariotti@idi.it., Andreani M; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Marzano AV; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Milan, Italy., De Simone C; Dermatology, Department of Medical and Surgery Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Falcone R; Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Testa G; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Battarra M; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Romagnuolo M; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Sollena P; Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Dermatology, Gemelli Isola - Ospedale Isola Tiberina, Rome, Italy., De Galitiis F; Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Antiga E; Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy., Maglie R; Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy., Didona D; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy; Dermatology Clinic, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Sinagra JLM; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Caproni M; Immunopathology and Rare Skin Diseases Unit, Section of Dermatology, Department of Health Sciences, Azienda Unità Sanitaria Locale Toscana Centro, University of Florence, Florence, Italy., Hertl M; Department of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany., Cozzani E; Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino Polyclinic Hospital, University of Genoa, Genoa, Italy., Vezzoli P; Dermatology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy., Calabrese L; Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, Siena, Italy., Paolino G; Unit of Dermatology, IRCCS Ospedale San Raffaele, Milan, Italy., Verkhovskaia S; Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Fania L; Dermatology Clinic, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy; Department of Life Science, Health, and Health Professions, Link University of Rome, Rome, Italy., Gasparini G; Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino Polyclinic Hospital, University of Genoa, Genoa, Italy., Giampetruzzi AR; Dermatology Clinic, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Didona B; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Quaglino P; Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy., Di Zenzo G; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.
Source: Acta dermato-venereologica [Acta Derm Venereol] 2026 Jun 29; Vol. 106. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: MJS Publishing Country of Publication: Sweden NLM ID: 0370310 Publication Model: Electronic Cited Medium: Internet ISSN: 1651-2057 (Electronic) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE
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  Data: Distinctive Reactivity to the C-terminal Epitope of BP180 Characterizes Immune Checkpoint Inhibitor-associated Bullous Pemphigoid, and an ELISA Based on the BP180 Ectodomain Enables Prompt Diagnosis in a Subset of Patients.
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  Data: <searchLink fieldCode="AU" term="%22Pira+A%22">Pira A</searchLink>; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Merli+M%22">Merli M</searchLink>; Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; Dermatology Clinic, Department of Medical Sciences, A.O. Ordine Mauriziano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Mariotti+F%22">Mariotti F</searchLink>; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy. f.mariotti@idi.it.<br /><searchLink fieldCode="AU" term="%22Andreani+M%22">Andreani M</searchLink>; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Marzano+AV%22">Marzano AV</searchLink>; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Simone+C%22">De Simone C</searchLink>; Dermatology, Department of Medical and Surgery Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Falcone+R%22">Falcone R</searchLink>; Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Testa+G%22">Testa G</searchLink>; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Battarra+M%22">Battarra M</searchLink>; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Romagnuolo+M%22">Romagnuolo M</searchLink>; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Sollena+P%22">Sollena P</searchLink>; Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Dermatology, Gemelli Isola - Ospedale Isola Tiberina, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Galitiis+F%22">De Galitiis F</searchLink>; Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antiga+E%22">Antiga E</searchLink>; Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Maglie+R%22">Maglie R</searchLink>; Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Didona+D%22">Didona D</searchLink>; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy; Dermatology Clinic, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sinagra+JLM%22">Sinagra JLM</searchLink>; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Caproni+M%22">Caproni M</searchLink>; Immunopathology and Rare Skin Diseases Unit, Section of Dermatology, Department of Health Sciences, Azienda Unità Sanitaria Locale Toscana Centro, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Hertl+M%22">Hertl M</searchLink>; Department of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Cozzani+E%22">Cozzani E</searchLink>; Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino Polyclinic Hospital, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Vezzoli+P%22">Vezzoli P</searchLink>; Dermatology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Calabrese+L%22">Calabrese L</searchLink>; Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Paolino+G%22">Paolino G</searchLink>; Unit of Dermatology, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Verkhovskaia+S%22">Verkhovskaia S</searchLink>; Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fania+L%22">Fania L</searchLink>; Dermatology Clinic, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy; Department of Life Science, Health, and Health Professions, Link University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gasparini+G%22">Gasparini G</searchLink>; Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino Polyclinic Hospital, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Giampetruzzi+AR%22">Giampetruzzi AR</searchLink>; Dermatology Clinic, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Didona+B%22">Didona B</searchLink>; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Quaglino+P%22">Quaglino P</searchLink>; Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Zenzo+G%22">Di Zenzo G</searchLink>; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.
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