Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.
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| Title: | Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs. |
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| Authors: | Koopman LA; Genmab (Netherlands) Utrecht Netherlands., Alemdehy F; Genmab (Netherlands) Utrecht Netherlands., de Poot SAH; Genmab (Netherlands) Utrecht Netherlands., Paauwe M; Genmab (Netherlands) Utrecht Netherlands., Wang W; Genmab (Netherlands) Utrecht Netherlands., Epstein KR; University of Pennsylvania Philadelphia United States., van den Brink EN; Genmab (Netherlands) Utrecht Netherlands., Gorlani A; Genmab (Netherlands) Utrecht Netherlands., Verzijl D; Genmab (Netherlands) Utrecht Netherlands., Brandhorst M; Genmab (Netherlands) Utrecht Netherlands., Franken P; Genmab (Netherlands) Utrecht Netherlands., Smits-de Vries L; Genmab (Netherlands) Utrecht Netherlands., Gielen E; Genmab (Netherlands) Utrecht Netherlands., Plantinga TS; Genmab (Netherlands) Utrecht Netherlands., Houtkamp M; Genmab (Netherlands) Utrecht Netherlands., Engelberts PJ; Genmab (Netherlands) Utrecht Netherlands., Lihme Egerod F; Genmab (Denmark) Copenhagen Denmark., Thalhauser CJ; Genmab (United States) Plainsboro, New Jersey United States., Bosgra S; Genmab (Netherlands) Utrecht Netherlands., Gitto SB; University of Pennsylvania Philadelphia, PA United States., Powell DJ; University of Pennsylvania Philadelphia, PA United States., Gamse JT; Genmab (United States) Plainsboro, NJ United States., Overdijk MB; Genmab (Netherlands) Utrecht, utrecht Netherlands., Breij ECW; Genmab (Netherlands) Utrecht Netherlands. |
| Source: | Molecular cancer therapeutics [Mol Cancer Ther] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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