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Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.

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Title: Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.
Authors: Henderson D; Faculty of Medicine, Université Paris Cité, Paris, France.; Institut Hospitalo-Universitaire Reconnect, Lariboisière Hospital, Assistance Publique - Hopitaux de Paris, Paris, France., Knoedler L; Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Mathieu O; Faculty of Medicine, Université Paris Cité, Paris, France.; Department of Plastic and Reconstructive Surgery, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, Paris, France., Rouas-Freiss N; Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF)-Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM) U1342, Institut de Recherche Saint-Louis, Université Paris Cité Paris, Paris, France., Cetrulo CL; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Hospital, Los Angeles, CA, United States.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Lemaitre G; Université Evry/Paris-Saclay, Evry, France.; Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Inserm, Institut de Biologie François Jacob, Département de Radiobiologie Cellulaire et Moléculaire, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.; Laboratoire de Régénération et Radiopathologies Cutanées (LR2C), Evry, France., Smadja DM; Université Paris Cité, Inserm, The Paris Cardiovascular Research Center, Team Endotheliopathy and Hemostasis Disorders, Paris, France.; AP-HP, Hôpital Européen Georges Pompidou, Hematology Department, Paris, France., Fortunel NO; Université Evry/Paris-Saclay, Evry, France.; Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Inserm, Institut de Biologie François Jacob, Département de Radiobiologie Cellulaire et Moléculaire, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.; Laboratoire de Régénération et Radiopathologies Cutanées (LR2C), Evry, France.; Université Paris-Saclay, Gif-sur-Yvette, France., Lellouch AG; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Hospital, Los Angeles, CA, United States.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.; Université Paris Cité, Inserm, The Paris Cardiovascular Research Center, Team Endotheliopathy and Hemostasis Disorders, Paris, France.; AP-HP, Hôpital Européen Georges Pompidou, Hematology Department, Paris, France.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 15; Vol. 17, pp. 1866007. Date of Electronic Publication: 2026 Jun 15 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.
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  Data: <searchLink fieldCode="AU" term="%22Henderson+D%22">Henderson D</searchLink>; Faculty of Medicine, Université Paris Cité, Paris, France.; Institut Hospitalo-Universitaire Reconnect, Lariboisière Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Knoedler+L%22">Knoedler L</searchLink>; Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mathieu+O%22">Mathieu O</searchLink>; Faculty of Medicine, Université Paris Cité, Paris, France.; Department of Plastic and Reconstructive Surgery, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rouas-Freiss+N%22">Rouas-Freiss N</searchLink>; Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF)-Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM) U1342, Institut de Recherche Saint-Louis, Université Paris Cité Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cetrulo+CL%22">Cetrulo CL</searchLink>; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Hospital, Los Angeles, CA, United States.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Lemaitre+G%22">Lemaitre G</searchLink>; Université Evry/Paris-Saclay, Evry, France.; Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Inserm, Institut de Biologie François Jacob, Département de Radiobiologie Cellulaire et Moléculaire, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.; Laboratoire de Régénération et Radiopathologies Cutanées (LR2C), Evry, France.<br /><searchLink fieldCode="AU" term="%22Smadja+DM%22">Smadja DM</searchLink>; Université Paris Cité, Inserm, The Paris Cardiovascular Research Center, Team Endotheliopathy and Hemostasis Disorders, Paris, France.; AP-HP, Hôpital Européen Georges Pompidou, Hematology Department, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fortunel+NO%22">Fortunel NO</searchLink>; Université Evry/Paris-Saclay, Evry, France.; Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Inserm, Institut de Biologie François Jacob, Département de Radiobiologie Cellulaire et Moléculaire, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.; Laboratoire de Régénération et Radiopathologies Cutanées (LR2C), Evry, France.; Université Paris-Saclay, Gif-sur-Yvette, France.<br /><searchLink fieldCode="AU" term="%22Lellouch+AG%22">Lellouch AG</searchLink>; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Hospital, Los Angeles, CA, United States.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.; Université Paris Cité, Inserm, The Paris Cardiovascular Research Center, Team Endotheliopathy and Hemostasis Disorders, Paris, France.; AP-HP, Hôpital Européen Georges Pompidou, Hematology Department, Paris, France.
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