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Reduced peroxisomal function increases insulin secretion, promotes insulin oxidation, and impairs β cell maturity.

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Title: Reduced peroxisomal function increases insulin secretion, promotes insulin oxidation, and impairs β cell maturity.
Authors: Collier JJ; Pennington Biomedical Research Center, Baton Rouge, United States of America., Cothern CR; Pennington Biomedical Research Center, Baton Rouge, United States of America., Ducote MP; Pennington Biomedical Research Center, Baton Rouge, United States of America., Martin TM; Pennington Biomedical Research Center, Baton Rouge, United States of America., Linden MA; Pennington Biomedical Research Center, Baton Rouge, United States of America., Noland RC; Pennington Biomedical Research Center, Baton Rouge, United States of America., Burk DH; Pennington Biomedical Research Center, Baton Rouge, United States of America., Dupuy SD; Department of Surgery, The University of Tennessee Graduate School of Medicine, Knoxville, United States of America., Karlstad MD; Department of Surgery, The University of Tennessee Graduate School of Medicine, Knoxville, United States of America., Stadler K; Pennington Biomedical Research Center, Baton Rouge, United States of America., Hirschbeck SS; Department of Chemistry, The University of Tennessee, Knoxville, United States of America., Do TD; Department of Chemistry, The University of Tennessee, Knoxville, United States of America., Coldren A; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, United States of America., Brissova M; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, United States of America., Kim T; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, United States of America., Habegger KM; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, United States of America., Ghosh S; Pennington Biomedical Research Center, Baton Rouge, United States of America., Vickery ZA; Department of Chemistry, The University of Tennessee, Knoxville, United States of America., Sarumi Q; Department of Chemistry, The University of Tennessee, Knoxville, United States of America., Campagna SR; Department of Chemistry, The University of Tennessee, Knoxville, United States of America., Burke SJ; Pennington Biomedical Research Center, Baton Rouge, United States of America.
Source: JCI insight [JCI Insight] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: Reduced peroxisomal function increases insulin secretion, promotes insulin oxidation, and impairs β cell maturity.
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  Data: <searchLink fieldCode="AU" term="%22Collier+JJ%22">Collier JJ</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Cothern+CR%22">Cothern CR</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Ducote+MP%22">Ducote MP</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Martin+TM%22">Martin TM</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Linden+MA%22">Linden MA</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Noland+RC%22">Noland RC</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Burk+DH%22">Burk DH</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Dupuy+SD%22">Dupuy SD</searchLink>; Department of Surgery, The University of Tennessee Graduate School of Medicine, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Karlstad+MD%22">Karlstad MD</searchLink>; Department of Surgery, The University of Tennessee Graduate School of Medicine, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Stadler+K%22">Stadler K</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Hirschbeck+SS%22">Hirschbeck SS</searchLink>; Department of Chemistry, The University of Tennessee, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Do+TD%22">Do TD</searchLink>; Department of Chemistry, The University of Tennessee, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Coldren+A%22">Coldren A</searchLink>; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Brissova+M%22">Brissova M</searchLink>; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Kim+T%22">Kim T</searchLink>; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, United States of America.<br /><searchLink fieldCode="AU" term="%22Habegger+KM%22">Habegger KM</searchLink>; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, United States of America.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.<br /><searchLink fieldCode="AU" term="%22Vickery+ZA%22">Vickery ZA</searchLink>; Department of Chemistry, The University of Tennessee, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Sarumi+Q%22">Sarumi Q</searchLink>; Department of Chemistry, The University of Tennessee, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Campagna+SR%22">Campagna SR</searchLink>; Department of Chemistry, The University of Tennessee, Knoxville, United States of America.<br /><searchLink fieldCode="AU" term="%22Burke+SJ%22">Burke SJ</searchLink>; Pennington Biomedical Research Center, Baton Rouge, United States of America.
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