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Clinical and transcriptomic characterization of mixed granulocytic phenotype in chronic obstructive pulmonary disease.

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Title: Clinical and transcriptomic characterization of mixed granulocytic phenotype in chronic obstructive pulmonary disease.
Authors: Leung C; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Yoo JW; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Pulmonary Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea., Park HY; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea., Bhutta H; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Sidhu P; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Guinto E; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Koelwyn GJ; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Vahedi M; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Li X; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Eddy RL; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Department of Radiology, University of British Columbia, Vancouver, Canada., Leipsic JA; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Department of Radiology, University of British Columbia, Vancouver, Canada., Leitao Filho FS; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Pulmonary Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil., Yang JS; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Milne S; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Department of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, Australia; Sydney Medical School, The University of Sydney, Camperdown, Australia; Ludwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, Westmead, Australia., Takiguchi H; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan., Akata K; Division of Infection Control and Prevention, University of Occupational and Environmental Health, Kitakyushu City, Fukuoka, Japan., Ra SW; Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea., Moon JY; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea., Kim HK; Department of Internal Medicine, College of Medicine, Inje University Haeundae Paik Hospital, Busan, South Korea., Cho Y; Division of Pulmonary Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea., Yamasaki K; Department of Respiratory Medicine, University of Occupational and Environmental Health Japan, Fukuoka, Japan., van Eeden SF; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Shaipanich T; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Lam S; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; British Columbia Cancer Research Institute, Vancouver, Canada., Leung JM; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada., Sin DD; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: don.sin@hli.ubc.ca.
Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Clinical and transcriptomic characterization of mixed granulocytic phenotype in chronic obstructive pulmonary disease.
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  Data: <searchLink fieldCode="AU" term="%22Leung+C%22">Leung C</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Yoo+JW%22">Yoo JW</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Pulmonary Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+HY%22">Park HY</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea.<br /><searchLink fieldCode="AU" term="%22Bhutta+H%22">Bhutta H</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Sidhu+P%22">Sidhu P</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.<br /><searchLink fieldCode="AU" term="%22Guinto+E%22">Guinto E</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Koelwyn+GJ%22">Koelwyn GJ</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.<br /><searchLink fieldCode="AU" term="%22Vahedi+M%22">Vahedi M</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Eddy+RL%22">Eddy RL</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Department of Radiology, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Leipsic+JA%22">Leipsic JA</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Department of Radiology, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Leitao+Filho+FS%22">Leitao Filho FS</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Division of Pulmonary Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Yang+JS%22">Yang JS</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Milne+S%22">Milne S</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; Department of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, Australia; Sydney Medical School, The University of Sydney, Camperdown, Australia; Ludwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Takiguchi+H%22">Takiguchi H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan.<br /><searchLink fieldCode="AU" term="%22Akata+K%22">Akata K</searchLink>; Division of Infection Control and Prevention, University of Occupational and Environmental Health, Kitakyushu City, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Ra+SW%22">Ra SW</searchLink>; Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Moon+JY%22">Moon JY</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HK%22">Kim HK</searchLink>; Department of Internal Medicine, College of Medicine, Inje University Haeundae Paik Hospital, Busan, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+Y%22">Cho Y</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea.<br /><searchLink fieldCode="AU" term="%22Yamasaki+K%22">Yamasaki K</searchLink>; Department of Respiratory Medicine, University of Occupational and Environmental Health Japan, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22van+Eeden+SF%22">van Eeden SF</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Shaipanich+T%22">Shaipanich T</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Lam+S%22">Lam S</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada; British Columbia Cancer Research Institute, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Leung+JM%22">Leung JM</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Sin+DD%22">Sin DD</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: don.sin@hli.ubc.ca.
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