View in EDS

Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration.

Saved in:
Bibliographic Details
Title: Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration.
Authors: Leahey RR; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Weber M; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Cho CH; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, CA, 94080, USA., Hur SK; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Cramer A; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Manzanares K; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA., Babin B; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA., Boenig G; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, 94080, USA., Kring T; Department of Pharmaceutics, Genentech, Inc., South San Francisco, CA, 94080, USA., Liu L; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Cui Y; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Ganti A; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Evans JP; Arctoris Ltd, 120E Olympic Avenue, OX14 4SA, Abingdon, United Kingdom., Nespi M; Department of Pharmaceutics, Genentech, Inc., South San Francisco, CA, 94080, USA., Ly J; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Nugent AA; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, CA, 94080, USA., Green SA; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, 94080, USA., Chan BK; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, 94080, USA., Hoogenraad CC; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Delwig A; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA. delwig.anton@gene.com., Hinz FI; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA. hinz.flora@gene.com.
Source: Npj drug discovery [NPJ Drug Discov] 2025 Aug 25; Vol. 2 (1). Date of Electronic Publication: 2025 Aug 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918993695206676 Publication Model: Electronic Cited Medium: Internet ISSN: 3005-1452 (Electronic) Linking ISSN: 30051452 NLM ISO Abbreviation: NPJ Drug Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42380237
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Leahey+RR%22">Leahey RR</searchLink>; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Weber+M%22">Weber M</searchLink>; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Cho+CH%22">Cho CH</searchLink>; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Hur+SK%22">Hur SK</searchLink>; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Cramer+A%22">Cramer A</searchLink>; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Manzanares+K%22">Manzanares K</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Babin+B%22">Babin B</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Boenig+G%22">Boenig G</searchLink>; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Kring+T%22">Kring T</searchLink>; Department of Pharmaceutics, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ganti+A%22">Ganti A</searchLink>; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Evans+JP%22">Evans JP</searchLink>; Arctoris Ltd, 120E Olympic Avenue, OX14 4SA, Abingdon, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Nespi+M%22">Nespi M</searchLink>; Department of Pharmaceutics, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ly+J%22">Ly J</searchLink>; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Nugent+AA%22">Nugent AA</searchLink>; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Green+SA%22">Green SA</searchLink>; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chan+BK%22">Chan BK</searchLink>; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Hoogenraad+CC%22">Hoogenraad CC</searchLink>; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Delwig+A%22">Delwig A</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA. delwig.anton@gene.com.<br /><searchLink fieldCode="AU" term="%22Hinz+FI%22">Hinz FI</searchLink>; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA. hinz.flora@gene.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229918993695206676%22">Npj drug discovery</searchLink> [NPJ Drug Discov] 2025 Aug 25; Vol. 2 (1). <i>Date of Electronic Publication: </i>2025 Aug 25.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918993695206676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>3005-1452 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2230051452%22">30051452 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Drug Discov <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42380237
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44386-025-00023-4
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Leahey RR
      – PersonEntity:
          Name:
            NameFull: Weber M
      – PersonEntity:
          Name:
            NameFull: Cho CH
      – PersonEntity:
          Name:
            NameFull: Hur SK
      – PersonEntity:
          Name:
            NameFull: Cramer A
      – PersonEntity:
          Name:
            NameFull: Manzanares K
      – PersonEntity:
          Name:
            NameFull: Babin B
      – PersonEntity:
          Name:
            NameFull: Boenig G
      – PersonEntity:
          Name:
            NameFull: Kring T
      – PersonEntity:
          Name:
            NameFull: Liu L
      – PersonEntity:
          Name:
            NameFull: Cui Y
      – PersonEntity:
          Name:
            NameFull: Ganti A
      – PersonEntity:
          Name:
            NameFull: Evans JP
      – PersonEntity:
          Name:
            NameFull: Nespi M
      – PersonEntity:
          Name:
            NameFull: Ly J
      – PersonEntity:
          Name:
            NameFull: Nugent AA
      – PersonEntity:
          Name:
            NameFull: Green SA
      – PersonEntity:
          Name:
            NameFull: Chan BK
      – PersonEntity:
          Name:
            NameFull: Hoogenraad CC
      – PersonEntity:
          Name:
            NameFull: Delwig A
      – PersonEntity:
          Name:
            NameFull: Hinz FI
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 08
              Text: 2025 Aug 25
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 3005-1452
          Numbering:
            – Type: volume
              Value: 2
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Npj drug discovery
              Type: main
ResultId 1