Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration.
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| Title: | Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration. |
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| Authors: | Leahey RR; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Weber M; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Cho CH; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, CA, 94080, USA., Hur SK; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Cramer A; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Manzanares K; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA., Babin B; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA., Boenig G; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, 94080, USA., Kring T; Department of Pharmaceutics, Genentech, Inc., South San Francisco, CA, 94080, USA., Liu L; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Cui Y; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Ganti A; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Evans JP; Arctoris Ltd, 120E Olympic Avenue, OX14 4SA, Abingdon, United Kingdom., Nespi M; Department of Pharmaceutics, Genentech, Inc., South San Francisco, CA, 94080, USA., Ly J; Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, 94080, USA., Nugent AA; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, CA, 94080, USA., Green SA; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, 94080, USA., Chan BK; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, 94080, USA., Hoogenraad CC; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Delwig A; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, 94080, USA. delwig.anton@gene.com., Hinz FI; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA. hinz.flora@gene.com. |
| Source: | Npj drug discovery [NPJ Drug Discov] 2025 Aug 25; Vol. 2 (1). Date of Electronic Publication: 2025 Aug 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918993695206676 Publication Model: Electronic Cited Medium: Internet ISSN: 3005-1452 (Electronic) Linking ISSN: 30051452 NLM ISO Abbreviation: NPJ Drug Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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