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Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer.

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Title: Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer.
Authors: Bozkurt E; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.; Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA, 24061, USA., Kisakol B; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland., Dussmann H; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland., Lucantoni F; Laboratory of Cellular Stress and Cell Death Pathways, Centro de Investigación Príncipe Felipe (CIPF), Valencia, 46012, Spain., Sturrock A; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland., Azimi M; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.; Institute of Microbiology and Virology, Riga Stradins University, LV-1067, Riga, Latvia., Cho S; GE HealthCare Technology & Innovation Center (Formerly GE Research Center), 1 Research Circle, Niskayuna, NY, 12309, USA., McDonough E; GE HealthCare Technology & Innovation Center (Formerly GE Research Center), 1 Research Circle, Niskayuna, NY, 12309, USA., Fay J; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., O'Grady T; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Burke JP; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., McCawley N; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., McNamara DA; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Longley DB; Queens University, School of Medicine, Dentistry and Biomedical Sciences, Patrick G Johnston Centre for Cancer Research, 97 Lisburn Road, Belfast, BT9 AE, UK., Ginty F; GE HealthCare Technology & Innovation Center (Formerly GE Research Center), 1 Research Circle, Niskayuna, NY, 12309, USA., Prehn JHM; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland. prehn@rcsi.ie.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bozkurt+E%22">Bozkurt E</searchLink>; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.; Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Kisakol+B%22">Kisakol B</searchLink>; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Dussmann+H%22">Dussmann H</searchLink>; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Lucantoni+F%22">Lucantoni F</searchLink>; Laboratory of Cellular Stress and Cell Death Pathways, Centro de Investigación Príncipe Felipe (CIPF), Valencia, 46012, Spain.<br /><searchLink fieldCode="AU" term="%22Sturrock+A%22">Sturrock A</searchLink>; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Azimi+M%22">Azimi M</searchLink>; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland.; Institute of Microbiology and Virology, Riga Stradins University, LV-1067, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Cho+S%22">Cho S</searchLink>; GE HealthCare Technology & Innovation Center (Formerly GE Research Center), 1 Research Circle, Niskayuna, NY, 12309, USA.<br /><searchLink fieldCode="AU" term="%22McDonough+E%22">McDonough E</searchLink>; GE HealthCare Technology & Innovation Center (Formerly GE Research Center), 1 Research Circle, Niskayuna, NY, 12309, USA.<br /><searchLink fieldCode="AU" term="%22Fay+J%22">Fay J</searchLink>; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland.<br /><searchLink fieldCode="AU" term="%22O'Grady+T%22">O'Grady T</searchLink>; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland.<br /><searchLink fieldCode="AU" term="%22Burke+JP%22">Burke JP</searchLink>; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland.<br /><searchLink fieldCode="AU" term="%22McCawley+N%22">McCawley N</searchLink>; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland.<br /><searchLink fieldCode="AU" term="%22McNamara+DA%22">McNamara DA</searchLink>; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland.<br /><searchLink fieldCode="AU" term="%22Longley+DB%22">Longley DB</searchLink>; Queens University, School of Medicine, Dentistry and Biomedical Sciences, Patrick G Johnston Centre for Cancer Research, 97 Lisburn Road, Belfast, BT9 AE, UK.<br /><searchLink fieldCode="AU" term="%22Ginty+F%22">Ginty F</searchLink>; GE HealthCare Technology & Innovation Center (Formerly GE Research Center), 1 Research Circle, Niskayuna, NY, 12309, USA.<br /><searchLink fieldCode="AU" term="%22Prehn+JHM%22">Prehn JHM</searchLink>; Department of Physiology and Medical Physics & RCSI Centre for Systems Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland. prehn@rcsi.ie.
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