Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging.

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Title: Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging.
Authors: Oppezzo A; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Sepe S; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Cicio G; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Cancila V; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy., Sasso E; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, Italy.; ImGen-T Srl, Viale del Parco Carelli, Napoli, Italy., Conti A; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy., Marinelli E; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Cabrini M; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy., Pallavi R; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.; Prof. Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, India., Iacomino N; Neurology 4-Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Simoni M; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Malyshev D; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Russian Gerontology Research and Clinical Center, Pirogov Russian National Research Medical University, Moscow, Russia., Boggio S; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., di Lillo A; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Rosso I; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Tavella S; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy., Trastus LA; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Rossiello F; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Roscia G; VisMederi Srl, Siena, Italy., Cantaloni P; VisMederi Srl, Siena, Italy., Manenti A; VisMederi Srl, Siena, Italy., Cavalcante P; Neurology 4-Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Pelicci PG; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, Univesity of Milan, Milan, Italy., Di Micco R; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University School of Advanced Studies IUSS, Pavia, Italy., Nicosia A; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, Italy.; ImGen-T Srl, Viale del Parco Carelli, Napoli, Italy., Tripodo C; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Oncology and Hematology-Oncology, Univesity of Milan, Milan, Italy., d'Adda di Fagagna F; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy. fabrizio.dadda@ifom.eu.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy. fabrizio.dadda@ifom.eu.
Source: Nature aging [Nat Aging] 2026 Jul; Vol. 6 (7), pp. 1377-1394. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8465
DOI:10.1038/s43587-026-01136-9