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Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging.

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Title: Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging.
Authors: Oppezzo A; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Sepe S; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Cicio G; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Cancila V; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy., Sasso E; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, Italy.; ImGen-T Srl, Viale del Parco Carelli, Napoli, Italy., Conti A; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy., Marinelli E; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Cabrini M; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy., Pallavi R; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.; Prof. Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, India., Iacomino N; Neurology 4-Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Simoni M; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Malyshev D; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Russian Gerontology Research and Clinical Center, Pirogov Russian National Research Medical University, Moscow, Russia., Boggio S; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., di Lillo A; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Rosso I; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Tavella S; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy., Trastus LA; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Rossiello F; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Roscia G; VisMederi Srl, Siena, Italy., Cantaloni P; VisMederi Srl, Siena, Italy., Manenti A; VisMederi Srl, Siena, Italy., Cavalcante P; Neurology 4-Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Pelicci PG; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, Univesity of Milan, Milan, Italy., Di Micco R; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University School of Advanced Studies IUSS, Pavia, Italy., Nicosia A; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, Italy.; ImGen-T Srl, Viale del Parco Carelli, Napoli, Italy., Tripodo C; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Oncology and Hematology-Oncology, Univesity of Milan, Milan, Italy., d'Adda di Fagagna F; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy. fabrizio.dadda@ifom.eu.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy. fabrizio.dadda@ifom.eu.
Source: Nature aging [Nat Aging] 2026 Jul; Vol. 6 (7), pp. 1377-1394. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging.
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  Data: <searchLink fieldCode="AU" term="%22Oppezzo+A%22">Oppezzo A</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sepe+S%22">Sepe S</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cicio+G%22">Cicio G</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cancila+V%22">Cancila V</searchLink>; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Sasso+E%22">Sasso E</searchLink>; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, Italy.; ImGen-T Srl, Viale del Parco Carelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+A%22">Conti A</searchLink>; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marinelli+E%22">Marinelli E</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cabrini+M%22">Cabrini M</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Pallavi+R%22">Pallavi R</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.; Prof. Brien Holden Eye Research Centre, L. 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Prasad Eye Institute, Hyderabad, India.<br /><searchLink fieldCode="AU" term="%22Iacomino+N%22">Iacomino N</searchLink>; Neurology 4-Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Simoni+M%22">Simoni M</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Malyshev+D%22">Malyshev D</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Russian Gerontology Research and Clinical Center, Pirogov Russian National Research Medical University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Boggio+S%22">Boggio S</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22di+Lillo+A%22">di Lillo A</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rosso+I%22">Rosso I</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tavella+S%22">Tavella S</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Trastus+LA%22">Trastus LA</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rossiello+F%22">Rossiello F</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Roscia+G%22">Roscia G</searchLink>; VisMederi Srl, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Cantaloni+P%22">Cantaloni P</searchLink>; VisMederi Srl, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Manenti+A%22">Manenti A</searchLink>; VisMederi Srl, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Cavalcante+P%22">Cavalcante P</searchLink>; Neurology 4-Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pelicci+PG%22">Pelicci PG</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, Univesity of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Micco+R%22">Di Micco R</searchLink>; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University School of Advanced Studies IUSS, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Nicosia+A%22">Nicosia A</searchLink>; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, Italy.; ImGen-T Srl, Viale del Parco Carelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Tripodo+C%22">Tripodo C</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Oncology and Hematology-Oncology, Univesity of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22d'Adda+di+Fagagna+F%22">d'Adda di Fagagna F</searchLink>; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy. fabrizio.dadda@ifom.eu.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy. fabrizio.dadda@ifom.eu.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Jul; Vol. 6 (7), pp. 1377-1394. <i>Date of Electronic Publication: </i>2026 Jun 30.
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