Long-term outcomes of adjuvant metronomic capecitabine in locoregionally advanced nasopharyngeal carcinoma: a randomized, controlled, multicenter, phase 3 study.
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| Title: | Long-term outcomes of adjuvant metronomic capecitabine in locoregionally advanced nasopharyngeal carcinoma: a randomized, controlled, multicenter, phase 3 study. |
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| Authors: | Tao YL; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Wu DH; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhou Q; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Yang KY; Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Jin F; Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China., Zhu XD; Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Department of Oncology, Affiliated Wuming Hospital of Guangxi Medical University, Nanning, China., Shi M; Department of Radiation Oncology, Xijing Hospital of Fourth Military Medical University, Xi'an, China., Hu GQ; Department of Oncology, Cancer Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Sun Y; Department of Radiation Oncology, Peking University Cancer Hospital, Beijing, China., Wu HF; Department of Radiation Oncology, Jilin Cancer Hospital, Changchun, China., Wu H; Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, China., Lin Q; Department of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China., Wang H; Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China., Tian Y; Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China., Zhang N; Department of Radiation Oncology, The First People's Hospital of Foshan, Foshan, China., Wang XC; Department of Radiation Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China., Shen LF; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Liu ZZ; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Huang J; Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Luo XL; Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China., Li L; Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Department of Oncology, Affiliated Wuming Hospital of Guangxi Medical University, Nanning, China., Zang J; Department of Radiation Oncology, Xijing Hospital of Fourth Military Medical University, Xi'an, China., Mei Q; Department of Oncology, Cancer Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Zheng BM; Department of Radiation Oncology, Peking University Cancer Hospital, Beijing, China., Yue D; Department of Radiation Oncology, Jilin Cancer Hospital, Changchun, China., Xu J; Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, China., Wu SG; Department of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China., Chen L; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Li WF; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhou GQ; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Sun R; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Guo R; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhang Y; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Xu C; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Lv JW; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Guo Y; Clinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, China., Feng HX; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Tang LL; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Xie FY; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu X; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. liuxu@sysucc.org.cn., Sun Y; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. sunying@sysucc.org.cn., Ma J; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. majun2@mail.sysu.edu.cn., Mao YP; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. maoyp@sysucc.org.cn., Chen YP; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. chenyup1@sysucc.org.cn. |
| Source: | Nature cancer [Nat Cancer] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42380630 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Long-term outcomes of adjuvant metronomic capecitabine in locoregionally advanced nasopharyngeal carcinoma: a randomized, controlled, multicenter, phase 3 study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tao+YL%22">Tao YL</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+DH%22">Wu DH</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Yang+KY%22">Yang KY</searchLink>; Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Zhu+XD%22">Zhu XD</searchLink>; Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Department of Oncology, Affiliated Wuming Hospital of Guangxi Medical University, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Department of Radiation Oncology, Xijing Hospital of Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Hu+GQ%22">Hu GQ</searchLink>; Department of Oncology, Cancer Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Radiation Oncology, Peking University Cancer Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+HF%22">Wu HF</searchLink>; Department of Radiation Oncology, Jilin Cancer Hospital, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+Q%22">Lin Q</searchLink>; Department of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Department of Radiation Oncology, The First People's Hospital of Foshan, Foshan, China.<br /><searchLink fieldCode="AU" term="%22Wang+XC%22">Wang XC</searchLink>; Department of Radiation Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+LF%22">Shen LF</searchLink>; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Liu+ZZ%22">Liu ZZ</searchLink>; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Luo+XL%22">Luo XL</searchLink>; Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Department of Oncology, Affiliated Wuming Hospital of Guangxi Medical University, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Zang+J%22">Zang J</searchLink>; Department of Radiation Oncology, Xijing Hospital of Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Mei+Q%22">Mei Q</searchLink>; Department of Oncology, Cancer Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zheng+BM%22">Zheng BM</searchLink>; Department of Radiation Oncology, Peking University Cancer Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yue+D%22">Yue D</searchLink>; Department of Radiation Oncology, Jilin Cancer Hospital, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+SG%22">Wu SG</searchLink>; Department of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+WF%22">Li WF</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+GQ%22">Zhou GQ</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Guo+R%22">Guo R</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lv+JW%22">Lv JW</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Clinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Feng+HX%22">Feng HX</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tang+LL%22">Tang LL</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+FY%22">Xie FY</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. liuxu@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. sunying@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. majun2@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Mao+YP%22">Mao YP</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. maoyp@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Chen+YP%22">Chen YP</searchLink>; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. chenyup1@sysucc.org.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2026 Jun 30. <i>Date of Electronic Publication: </i>2026 Jun 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101761119 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-1347 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226621347%22">26621347 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cancer <i>Subsets: </i>MEDLINE |
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