Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.
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| Title: | Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies. |
|---|---|
| Authors: | Marchitto L; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wagh K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Roark RS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Coleon S; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Skelly AN; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hogarty MP; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ding W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ayyanathan K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sheng Z; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Guo Y; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Bal J; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Smith LM; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Sutherland LL; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Connell AJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lewis E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Plante SJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Akeley MJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lora J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Carey JW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Martella CL; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campion MS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lituchy MG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Osbaldeston RA; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gordon CG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Albertus A; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Su J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Noguchi C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tam YK; Acuitas Therapeutics, Vancouver, BC, Canada., Barbosa C; Acuitas Therapeutics, Vancouver, BC, Canada., Liang B; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Walsh AA; Department of Immunology and Microbiology, Scripps Research Institure, La Jolla,, CA, USA., Irvine DJ; Department of Immunology and Microbiology, Scripps Research Institure, La Jolla,, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Edwards RJ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Kreider EF; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weissman D; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shapiro L; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Kwong PD; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA., Korber BT; Los Alamos National Laboratory, Los Alamos, NM, USA.; New Mexico Consortium, Los Alamos, NM, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.; Departments of Surgery, Molecular Genetics and Microbiology, and Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bhahn@pennmedicine.upenn.edu., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. shawg@pennmedicine.upenn.edu. |
| Source: | Nature [Nature] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42380659 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Marchitto+L%22">Marchitto L</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wagh+K%22">Wagh K</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Roark+RS%22">Roark RS</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA.<br /><searchLink fieldCode="AU" term="%22Coleon+S%22">Coleon S</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Skelly+AN%22">Skelly AN</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hogarty+MP%22">Hogarty MP</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Habib+R%22">Habib R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ding+W%22">Ding W</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ayyanathan+K%22">Ayyanathan K</searchLink>; 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Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Plante+SJ%22">Plante SJ</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Akeley+MJ%22">Akeley MJ</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lora+J%22">Lora J</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Carey+JW%22">Carey JW</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Martella+CL%22">Martella CL</searchLink>; 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Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+L%22">Shapiro L</searchLink>; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+PD%22">Kwong PD</searchLink>; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.<br /><searchLink fieldCode="AU" term="%22Korber+BT%22">Korber BT</searchLink>; Los Alamos National Laboratory, Los Alamos, NM, USA.; New Mexico Consortium, Los Alamos, NM, USA.<br /><searchLink fieldCode="AU" term="%22Haynes+BF%22">Haynes BF</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.; 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41586-026-10838-4 Languages: – Code: eng Text: English Titles: – TitleFull: Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Marchitto L – PersonEntity: Name: NameFull: Wagh K – PersonEntity: Name: NameFull: Roark RS – PersonEntity: Name: NameFull: Coleon S – PersonEntity: Name: NameFull: Li H – PersonEntity: Name: NameFull: Skelly AN – PersonEntity: Name: NameFull: Hogarty MP – PersonEntity: Name: NameFull: Habib R – PersonEntity: Name: NameFull: Ding W – PersonEntity: Name: NameFull: Ayyanathan K – PersonEntity: Name: NameFull: Liu W – PersonEntity: Name: NameFull: Sheng Z – PersonEntity: Name: NameFull: Guo Y – PersonEntity: Name: NameFull: Bal J – PersonEntity: Name: NameFull: Smith LM – PersonEntity: Name: NameFull: Sutherland LL – PersonEntity: Name: NameFull: Park Y – PersonEntity: Name: NameFull: Connell AJ – PersonEntity: Name: NameFull: Bibollet-Ruche F – PersonEntity: Name: NameFull: Lewis E – PersonEntity: Name: NameFull: Plante SJ – PersonEntity: Name: NameFull: Akeley MJ – PersonEntity: Name: NameFull: Lora J – PersonEntity: Name: NameFull: Zhao C – PersonEntity: Name: NameFull: Carey JW – PersonEntity: Name: NameFull: Martella CL – PersonEntity: Name: NameFull: Li Y – PersonEntity: Name: NameFull: Campion MS – PersonEntity: Name: NameFull: Lituchy MG – PersonEntity: Name: NameFull: Osbaldeston RA – PersonEntity: Name: NameFull: Gordon CG – PersonEntity: Name: NameFull: Albertus A – PersonEntity: Name: NameFull: Su J – PersonEntity: Name: NameFull: Noguchi C – PersonEntity: Name: NameFull: Tam YK – PersonEntity: Name: NameFull: Barbosa C – PersonEntity: Name: NameFull: Liang B – PersonEntity: Name: NameFull: Amereh K – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Walsh AA – PersonEntity: Name: NameFull: Irvine DJ – PersonEntity: Name: NameFull: Andrabi R – PersonEntity: Name: NameFull: Edwards RJ – PersonEntity: Name: NameFull: Kreider EF – PersonEntity: Name: NameFull: Weissman D – PersonEntity: Name: NameFull: Shapiro L – PersonEntity: Name: NameFull: Kwong PD – PersonEntity: Name: NameFull: Korber BT – PersonEntity: Name: NameFull: Haynes BF – PersonEntity: Name: NameFull: Saunders KO – PersonEntity: Name: NameFull: Hahn BH – PersonEntity: Name: NameFull: Shaw GM IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 06 Text: 2026 Jun 30 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1476-4687 Titles: – TitleFull: Nature Type: main |
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