Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.

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Title: Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.
Authors: Marchitto L; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wagh K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Roark RS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Coleon S; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Skelly AN; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hogarty MP; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ding W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ayyanathan K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sheng Z; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Guo Y; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Bal J; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Smith LM; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Sutherland LL; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Connell AJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lewis E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Plante SJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Akeley MJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lora J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Carey JW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Martella CL; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campion MS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lituchy MG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Osbaldeston RA; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gordon CG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Albertus A; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Su J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Noguchi C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tam YK; Acuitas Therapeutics, Vancouver, BC, Canada., Barbosa C; Acuitas Therapeutics, Vancouver, BC, Canada., Liang B; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Walsh AA; Department of Immunology and Microbiology, Scripps Research Institure, La Jolla,, CA, USA., Irvine DJ; Department of Immunology and Microbiology, Scripps Research Institure, La Jolla,, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Edwards RJ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Kreider EF; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weissman D; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shapiro L; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York,, NY, USA., Kwong PD; Aaron Diamond AIDS Research Center, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York,, NY, USA., Korber BT; Los Alamos National Laboratory, Los Alamos, NM, USA.; New Mexico Consortium, Los Alamos, NM, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.; Departments of Surgery, Molecular Genetics and Microbiology, and Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bhahn@pennmedicine.upenn.edu., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. shawg@pennmedicine.upenn.edu.
Source: Nature [Nature] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.
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              Text: 2026 Jun 30
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1