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Selective sensitivity of Ph-like B-cell acute lymphoblastic leukemia to BRG1 inhibition identifies a therapeutic vulnerability.

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Title: Selective sensitivity of Ph-like B-cell acute lymphoblastic leukemia to BRG1 inhibition identifies a therapeutic vulnerability.
Authors: Ayyadevara VSSA; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA., Perencsik R; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.; University of British Columbia, Vancouver, BC, Canada., Patil S; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA., Gaur S; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA., Paik A; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.; Southern Adventist University, Collegedale, TN, USA., Toma M; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University Philadelphia, Philadelphia, PA, USA., Wertheim G; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Geng H; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Skorski T; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University Philadelphia, Philadelphia, PA, USA.; Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University Philadelphia, Philadelphia, PA, USA.; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Swaminathan S; Department of Systems Biology, City of Hope Beckman Research Institute, Duarte, CA, USA.; Department of Pediatrics, City of Hope Beckman Research Institute, Duarte, CA, USA., Hurtz C; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Churtz@llu.edu.
Source: Leukemia [Leukemia] 2026 Aug; Vol. 40 (8), pp. 1824-1828. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Letter
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE; In Process
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  Data: Selective sensitivity of Ph-like B-cell acute lymphoblastic leukemia to BRG1 inhibition identifies a therapeutic vulnerability.
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  Data: <searchLink fieldCode="AU" term="%22Ayyadevara+VSSA%22">Ayyadevara VSSA</searchLink>; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perencsik+R%22">Perencsik R</searchLink>; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.; University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Patil+S%22">Patil S</searchLink>; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gaur+S%22">Gaur S</searchLink>; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.<br /><searchLink fieldCode="AU" term="%22Paik+A%22">Paik A</searchLink>; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.; Southern Adventist University, Collegedale, TN, USA.<br /><searchLink fieldCode="AU" term="%22Toma+M%22">Toma M</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wertheim+G%22">Wertheim G</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Geng+H%22">Geng H</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Skorski+T%22">Skorski T</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University Philadelphia, Philadelphia, PA, USA.; Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University Philadelphia, Philadelphia, PA, USA.; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Swaminathan+S%22">Swaminathan S</searchLink>; Department of Systems Biology, City of Hope Beckman Research Institute, Duarte, CA, USA.; Department of Pediatrics, City of Hope Beckman Research Institute, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hurtz+C%22">Hurtz C</searchLink>; Department of Basic Science, Division of Cancer Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Churtz@llu.edu.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2026 Aug; Vol. 40 (8), pp. 1824-1828. <i>Date of Electronic Publication: </i>2026 Jun 30.
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