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Engineering Cathepsin S Selective Chemical Probes and Antibody-Drug Conjugates through Substrate Profiling with Unnatural Amino Acids.

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Title: Engineering Cathepsin S Selective Chemical Probes and Antibody-Drug Conjugates through Substrate Profiling with Unnatural Amino Acids.
Authors: Łęcka M; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Gorzeń O; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Ćwilichowska-Puślecka N; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Nguyen J; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Majchrzak M; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Pippa V; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Jakimowicz P; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Wiśniewski J; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Dołęga-Kozierowski B; Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland., Kasprzak P; Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland., Turk B; Jozef Stefan Institute, 1000 Ljubljana,Slovenia.; Faculty of Chemistry and Chemical Engineering, University of Ljubljana, 1000 Ljubljana,Slovenia., Drąg M; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.; Centre for Chemical Biology, Institute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland., Matkowski R; Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland.; Department of Oncology, Faculty of Medicine, Wrocław Medical University, 50-367 Wroclaw.Poland., Poręba M; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16550-16569. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Engineering Cathepsin S Selective Chemical Probes and Antibody-Drug Conjugates through Substrate Profiling with Unnatural Amino Acids.
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  Data: <searchLink fieldCode="AU" term="%22Łęcka+M%22">Łęcka M</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Gorzeń+O%22">Gorzeń O</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Ćwilichowska-Puślecka+N%22">Ćwilichowska-Puślecka N</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Majchrzak+M%22">Majchrzak M</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Pippa+V%22">Pippa V</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Jakimowicz+P%22">Jakimowicz P</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Wiśniewski+J%22">Wiśniewski J</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Dołęga-Kozierowski+B%22">Dołęga-Kozierowski B</searchLink>; Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Kasprzak+P%22">Kasprzak P</searchLink>; Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Turk+B%22">Turk B</searchLink>; Jozef Stefan Institute, 1000 Ljubljana,Slovenia.; Faculty of Chemistry and Chemical Engineering, University of Ljubljana, 1000 Ljubljana,Slovenia.<br /><searchLink fieldCode="AU" term="%22Drąg+M%22">Drąg M</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.; Centre for Chemical Biology, Institute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Matkowski+R%22">Matkowski R</searchLink>; Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland.; Department of Oncology, Faculty of Medicine, Wrocław Medical University, 50-367 Wroclaw.Poland.<br /><searchLink fieldCode="AU" term="%22Poręba+M%22">Poręba M</searchLink>; Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16550-16569. <i>Date of Electronic Publication: </i>2026 Jun 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.6c00202
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      – TitleFull: Engineering Cathepsin S Selective Chemical Probes and Antibody-Drug Conjugates through Substrate Profiling with Unnatural Amino Acids.
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              Text: 2026 Jul 23
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