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Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

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Title: Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.
Authors: St-Denis-Bissonnette F; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Mediratta K; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Ho N; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Kirkby M; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Stalker A; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Muradia G; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Shrestha A; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Ardolino M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Lee SH; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Burger D; Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Mer A; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Wang L; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Regenerative Medicine Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Lavoie JR; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Source: Molecular therapy. Oncology [Mol Ther Oncol] 2026 Jun 10; Vol. 34 (3), pp. 201261. Date of Electronic Publication: 2026 Jun 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918752083706676 Publication Model: eCollection Cited Medium: Print ISSN: 2950-3299 (Print) Linking ISSN: 29503299 NLM ISO Abbreviation: Mol Ther Oncol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22St-Denis-Bissonnette+F%22">St-Denis-Bissonnette F</searchLink>; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Mediratta+K%22">Mediratta K</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Ho+N%22">Ho N</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Kirkby+M%22">Kirkby M</searchLink>; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Stalker+A%22">Stalker A</searchLink>; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Muradia+G%22">Muradia G</searchLink>; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Shrestha+A%22">Shrestha A</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Ardolino+M%22">Ardolino M</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Burger+D%22">Burger D</searchLink>; Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Mer+A%22">Mer A</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Regenerative Medicine Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Lavoie+JR%22">Lavoie JR</searchLink>; Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
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