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Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

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Title: Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.
Authors: Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Blew C; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Duggan MR; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Joynes C; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Gomez GT; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Drouin S; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Cordon J; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Chen J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA., Zhang J; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA., File B; Alkahest Inc., San Carlos, CA 94070, USA., Nanasi T; Alkahest Inc., San Carlos, CA 94070, USA., Lehallier B; Alkahest Inc., San Carlos, CA 94070, USA., Oh H; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA., Surapaneni A; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Grams ME; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Palta P; Department of Neurology, UNC School of Medicine, Chapel Hill, NC 27599, USA., Sullivan KJ; Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS 39216, USA., Pichet Binette A; Department of Physiology and Pharmacology, Université de Montréal, Montréal, Quebec H3C3J7, Canada.; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec H3W1W5, Canada.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund 221 00, Sweden., Wu L; Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.; Department of Interdisciplinary Oncology and Department of Genetics, LSU-LCMC Health Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Zhu J; Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.; Department of Interdisciplinary Oncology and Department of Genetics, LSU-LCMC Health Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Leonard H; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA., Singleton AB; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Gottesman RF; National Institute of Neurological Disorders and Stroke, Intramural Research Program, Bethesda, MD 20892, USA., Mosley TH; MIND Center and Division of Nephrology, University of Mississippi Medical Center, Jackson, MS 39216, USA., Chatterjee N; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA., Coresh J; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.; Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA., Schlosser P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA.; Institute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg, Germany, Freiburg 79106, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany.
Source: Science translational medicine [Sci Transl Med] 2026 Jul; Vol. 18 (856), pp. eadx4852. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.
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  Data: <searchLink fieldCode="AU" term="%22Walker+KA%22">Walker KA</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Blew+C%22">Blew C</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Duggan+MR%22">Duggan MR</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Joynes+C%22">Joynes C</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Gomez+GT%22">Gomez GT</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Drouin+S%22">Drouin S</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Cordon+J%22">Cordon J</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA.<br /><searchLink fieldCode="AU" term="%22File+B%22">File B</searchLink>; Alkahest Inc., San Carlos, CA 94070, USA.<br /><searchLink fieldCode="AU" term="%22Nanasi+T%22">Nanasi T</searchLink>; Alkahest Inc., San Carlos, CA 94070, USA.<br /><searchLink fieldCode="AU" term="%22Lehallier+B%22">Lehallier B</searchLink>; Alkahest Inc., San Carlos, CA 94070, USA.<br /><searchLink fieldCode="AU" term="%22Oh+H%22">Oh H</searchLink>; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Surapaneni+A%22">Surapaneni A</searchLink>; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Grams+ME%22">Grams ME</searchLink>; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Palta+P%22">Palta P</searchLink>; Department of Neurology, UNC School of Medicine, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+KJ%22">Sullivan KJ</searchLink>; Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS 39216, USA.<br /><searchLink fieldCode="AU" term="%22Pichet+Binette+A%22">Pichet Binette A</searchLink>; Department of Physiology and Pharmacology, Université de Montréal, Montréal, Quebec H3C3J7, Canada.; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec H3W1W5, Canada.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.; Department of Interdisciplinary Oncology and Department of Genetics, LSU-LCMC Health Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.; Department of Interdisciplinary Oncology and Department of Genetics, LSU-LCMC Health Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.<br /><searchLink fieldCode="AU" term="%22Leonard+H%22">Leonard H</searchLink>; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Gottesman+RF%22">Gottesman RF</searchLink>; National Institute of Neurological Disorders and Stroke, Intramural Research Program, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Mosley+TH%22">Mosley TH</searchLink>; MIND Center and Division of Nephrology, University of Mississippi Medical Center, Jackson, MS 39216, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+N%22">Chatterjee N</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ferrucci+L%22">Ferrucci L</searchLink>; Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Coresh+J%22">Coresh J</searchLink>; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.; Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Schlosser+P%22">Schlosser P</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21210, USA.; Institute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg, Germany, Freiburg 79106, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany.
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