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CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.

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Title: CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.
Authors: Rampotas A; Cancer Institute, University College London, WC1E 6DD London, UK., Wong ZC; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Gannon I; Cancer Institute, University College London, WC1E 6DD London, UK., Brierley CK; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK., Shen Y; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Benlabiod C; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Chee A; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK., Khan S; Cancer Institute, University College London, WC1E 6DD London, UK., Hayder N; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Cheung GW; Cancer Institute, University College London, WC1E 6DD London, UK., Mitsikakou M; Cancer Institute, University College London, WC1E 6DD London, UK., Murphy E; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Ferrari M; Autolus Ltd., W12 7FP London, UK., Bulek A; Autolus Ltd., W12 7FP London, UK., Rodriguez-Romera A; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Murphy L; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Olijnik AA; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Rodriguez-Justo M; Cancer Institute, University College London, WC1E 6DD London, UK., Marty C; INSERM UMR1287 Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France., Hitchcock I; University of York, YO10 5DD York, UK., Royston D; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, OX3 9DU Oxford, UK., Mead AJ; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK., Khan AO; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK., Lambert J; University College London Hospitals NHS Foundation Trust, NW1 2BU London, UK., Roddie C; Cancer Institute, University College London, WC1E 6DD London, UK., Psaila B; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, OX3 7DQ Oxford, UK., Pule MA; Cancer Institute, University College London, WC1E 6DD London, UK.
Source: Science translational medicine [Sci Transl Med] 2026 Jul; Vol. 18 (856), pp. eadz3553. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Rampotas+A%22">Rampotas A</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Wong+ZC%22">Wong ZC</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Gannon+I%22">Gannon I</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Brierley+CK%22">Brierley CK</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Benlabiod+C%22">Benlabiod C</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chee+A%22">Chee A</searchLink>; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Khan+S%22">Khan S</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Hayder+N%22">Hayder N</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cheung+GW%22">Cheung GW</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Mitsikakou+M%22">Mitsikakou M</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+E%22">Murphy E</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ferrari+M%22">Ferrari M</searchLink>; Autolus Ltd., W12 7FP London, UK.<br /><searchLink fieldCode="AU" term="%22Bulek+A%22">Bulek A</searchLink>; Autolus Ltd., W12 7FP London, UK.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Romera+A%22">Rodriguez-Romera A</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+L%22">Murphy L</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Olijnik+AA%22">Olijnik AA</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Justo+M%22">Rodriguez-Justo M</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Marty+C%22">Marty C</searchLink>; INSERM UMR1287 Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Hitchcock+I%22">Hitchcock I</searchLink>; University of York, YO10 5DD York, UK.<br /><searchLink fieldCode="AU" term="%22Royston+D%22">Royston D</searchLink>; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, OX3 9DU Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mead+AJ%22">Mead AJ</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Khan+AO%22">Khan AO</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lambert+J%22">Lambert J</searchLink>; University College London Hospitals NHS Foundation Trust, NW1 2BU London, UK.<br /><searchLink fieldCode="AU" term="%22Roddie+C%22">Roddie C</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Psaila+B%22">Psaila B</searchLink>; MRC Weatherall Institute of Molecular Medicine and National Institute of Health Research (NIHR) Biomedical Research Centre Cancer Theme, University of Oxford, OX3 9DS Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, OX3 7LE Oxford, UK.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, OX3 7DQ Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pule+MA%22">Pule MA</searchLink>; Cancer Institute, University College London, WC1E 6DD London, UK.
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