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Loss of O-antigen due to wbbL mutations is common and associated with increased mortality in Escherichia coli bloodstream infections.

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Title: Loss of O-antigen due to wbbL mutations is common and associated with increased mortality in Escherichia coli bloodstream infections.
Authors: Tyson KJ; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA., Velez AZ; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27559, USA., Hanson BM; Center for Infectious Diseases, University of Texas Health Science Center, Houston, TX 77030, USA., Jiang J; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Lu KY; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27559, USA., Ruffin F; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA., Sutton G; J. Craig Venter Institute, Rockville, MD 20850, USA.; National Institute of Health, Bethesda, MD 20892, USA., Brinkac LM; J. Craig Venter Institute, Rockville, MD 20850, USA.; Noblis, 2002 Edmund Halley Dr, Reston, VA 20191, USA., Clarke TH; J. Craig Venter Institute, Rockville, MD 20850, USA., Tao Y; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA., Fouts DE; J. Craig Venter Institute, Rockville, MD 20850, USA., Adams MD; J. Craig Venter Institute, Rockville, MD 20850, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Arias CA; Division of Infectious Diseases, Houston Methodist Hospital and Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX 77030, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Khandelwal S; Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA., Fowler VG Jr; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA., Thaden JT; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA., Conlon BP; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27559, USA., Parsons JB; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.
Source: Science advances [Sci Adv] 2026 Jul 03; Vol. 12 (27), pp. eaec4661. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Loss of O-antigen due to wbbL mutations is common and associated with increased mortality in Escherichia coli bloodstream infections.
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  Data: <searchLink fieldCode="AU" term="%22Tyson+KJ%22">Tyson KJ</searchLink>; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Velez+AZ%22">Velez AZ</searchLink>; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27559, USA.<br /><searchLink fieldCode="AU" term="%22Hanson+BM%22">Hanson BM</searchLink>; Center for Infectious Diseases, University of Texas Health Science Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.<br /><searchLink fieldCode="AU" term="%22Lu+KY%22">Lu KY</searchLink>; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27559, USA.<br /><searchLink fieldCode="AU" term="%22Ruffin+F%22">Ruffin F</searchLink>; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Sutton+G%22">Sutton G</searchLink>; J. Craig Venter Institute, Rockville, MD 20850, USA.; National Institute of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Brinkac+LM%22">Brinkac LM</searchLink>; J. Craig Venter Institute, Rockville, MD 20850, USA.; Noblis, 2002 Edmund Halley Dr, Reston, VA 20191, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+TH%22">Clarke TH</searchLink>; J. Craig Venter Institute, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Fouts+DE%22">Fouts DE</searchLink>; J. Craig Venter Institute, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Adams+MD%22">Adams MD</searchLink>; J. Craig Venter Institute, Rockville, MD 20850, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.<br /><searchLink fieldCode="AU" term="%22Arias+CA%22">Arias CA</searchLink>; Division of Infectious Diseases, Houston Methodist Hospital and Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX 77030, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Khandelwal+S%22">Khandelwal S</searchLink>; Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Fowler+VG+Jr%22">Fowler VG Jr</searchLink>; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Thaden+JT%22">Thaden JT</searchLink>; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Conlon+BP%22">Conlon BP</searchLink>; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27559, USA.<br /><searchLink fieldCode="AU" term="%22Parsons+JB%22">Parsons JB</searchLink>; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Jul 03; Vol. 12 (27), pp. eaec4661. <i>Date of Electronic Publication: </i>2026 Jul 01.
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