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Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).

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Title: Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).
Authors: Rodríguez-Freire C; Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain., Navarrete J; Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Rozadilla-Sacanell A; Department of Rheumatology, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain., Sanabria-Mazo JP; Unit for the Study and Treatment of Pain-ALGOS, Department of Psychology, Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain.; Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain., Del Pino-Gaya B; Department of Pharmacy, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain., Borràs X; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Basic, Developmental and Educational Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain., Feliu-Soler A; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain., Luciano JV; Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain.
Source: European journal of pain (London, England) [Eur J Pain] 2026 Jul; Vol. 30 (6), pp. e70321.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 9801774 Publication Model: Print Cited Medium: Internet ISSN: 1532-2149 (Electronic) Linking ISSN: 10903801 NLM ISO Abbreviation: Eur J Pain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).
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  Data: <searchLink fieldCode="AU" term="%22Rodríguez-Freire+C%22">Rodríguez-Freire C</searchLink>; Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Navarrete+J%22">Navarrete J</searchLink>; Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rozadilla-Sacanell+A%22">Rozadilla-Sacanell A</searchLink>; Department of Rheumatology, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Sanabria-Mazo+JP%22">Sanabria-Mazo JP</searchLink>; Unit for the Study and Treatment of Pain-ALGOS, Department of Psychology, Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain.; Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Pino-Gaya+B%22">Del Pino-Gaya B</searchLink>; Department of Pharmacy, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Borràs+X%22">Borràs X</searchLink>; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Basic, Developmental and Educational Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Feliu-Soler+A%22">Feliu-Soler A</searchLink>; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Luciano+JV%22">Luciano JV</searchLink>; Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain.
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  Data: <searchLink fieldCode="JN" term="%229801774%22">European journal of pain (London, England)</searchLink> [Eur J Pain] 2026 Jul; Vol. 30 (6), pp. e70321.
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              Text: 2026 Jul
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