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High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

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Title: High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.
Authors: Boyd A; Amsterdam UMC, Location University of Amsterdam, Department of Infectious Diseases, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands; Stichting HIV Monitoring, Amsterdam, the Netherlands., Daenen K; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: k.daenen@erasmusmc.nl., Stoof S; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands., van Willigen HDG; Department of Medical Microbiology & Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands; Department of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands., Gommers D; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands., Moeniralam HS; Department of Internal Medicine and Intensive Care, St. Antonius Ziekenhuis, Nieuwegein, the Netherlands., den Uil CA; Department of Intensive Care, Maasstad Ziekenhuis, Rotterdam, the Netherlands., Juffermans NP; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands., Kant M; Department of Pulmonology, Amphia Ziekenhuis, Breda, the Netherlands; Department of Intensive Care, Amphia Ziekenhuis, Breda, the Netherlands., Valkenburg AJ; Department of Anesthesiology and Intensive Care, Isala Ziekenhuis, Zwolle, the Netherlands., Pillay J; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van Gorp E; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Schinkel J; Department of Medical Microbiology & Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands; Department of Medical Microbiology, Section of Clinical Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Meenen DMP; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands., Goossen R; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands., Paulus F; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands., Dalm V; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands., Bos LDJ; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands., Endeman H; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Intensive Care, OLVG, Amsterdam, the Netherlands., Huijben JA; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands.
Corporate Authors: PRoVENT- and PRoAcT-COVID Collaborative Group
Source: Journal of critical care [J Crit Care] 2026 Jul 01; Vol. 95, pp. 155670. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8610642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8615 (Electronic) Linking ISSN: 08839441 NLM ISO Abbreviation: J Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.
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  Data: <searchLink fieldCode="AU" term="%22Boyd+A%22">Boyd A</searchLink>; Amsterdam UMC, Location University of Amsterdam, Department of Infectious Diseases, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands; Stichting HIV Monitoring, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Daenen+K%22">Daenen K</searchLink>; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: k.daenen@erasmusmc.nl.<br /><searchLink fieldCode="AU" term="%22Stoof+S%22">Stoof S</searchLink>; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Willigen+HDG%22">van Willigen HDG</searchLink>; Department of Medical Microbiology & Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands; Department of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gommers+D%22">Gommers D</searchLink>; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moeniralam+HS%22">Moeniralam HS</searchLink>; Department of Internal Medicine and Intensive Care, St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.<br /><searchLink fieldCode="AU" term="%22den+Uil+CA%22">den Uil CA</searchLink>; Department of Intensive Care, Maasstad Ziekenhuis, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Juffermans+NP%22">Juffermans NP</searchLink>; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kant+M%22">Kant M</searchLink>; Department of Pulmonology, Amphia Ziekenhuis, Breda, the Netherlands; Department of Intensive Care, Amphia Ziekenhuis, Breda, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Valkenburg+AJ%22">Valkenburg AJ</searchLink>; Department of Anesthesiology and Intensive Care, Isala Ziekenhuis, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pillay+J%22">Pillay J</searchLink>; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gorp+E%22">van Gorp E</searchLink>; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schinkel+J%22">Schinkel J</searchLink>; Department of Medical Microbiology & Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands; Department of Medical Microbiology, Section of Clinical Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Meenen+DMP%22">van Meenen DMP</searchLink>; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Goossen+R%22">Goossen R</searchLink>; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Paulus+F%22">Paulus F</searchLink>; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dalm+V%22">Dalm V</searchLink>; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Endeman+H%22">Endeman H</searchLink>; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Intensive Care, OLVG, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Huijben+JA%22">Huijben JA</searchLink>; Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%228610642%22">Journal of critical care</searchLink> [J Crit Care] 2026 Jul 01; Vol. 95, pp. 155670. <i>Date of Electronic Publication: </i>2026 Jul 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders%22">W.B. Saunders </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8610642 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-8615 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208839441%22">08839441 </searchLink><i>NLM ISO Abbreviation: </i>J Crit Care <i>Subsets: </i>MEDLINE
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