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Updated patient-reported outcomes and the effect of disease progression on health-related quality of life in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.

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Title: Updated patient-reported outcomes and the effect of disease progression on health-related quality of life in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.
Authors: Shahin MS; Division of Gynecologic Oncology, Penn State Hershey Medical Center, Hershey, PA, USA. Electronic address: mshahin@pennstatehealth.psu.edu., Lorusso D; Fondazione Istituto Nazionale Tumori, and Multicenter Italian Trials in Ovarian Cancer and Gynecologic Malignancies (MITO), Milan, Italy., Backes FJ; Division of Gynecologic Oncology, The Ohio State University, Columbus, OH, USA., Barretina-Ginesta MP; Medical Oncology Department, Institut Català d'Oncologia, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona University, Girona, and Grupo Español de Investigación en Cáncer ginecológicO (GEICO), Madrid, Spain., O'Malley DM; The Ohio State University and The James Comprehensive Cancer Center, Columbus, OH, USA., Forget F; Department of Medical Oncology, Hôpital Vivalia De Libramont, Libramont-Chevigny, Belgium., Pothuri B; Departments of Obstetrics/Gynecology and Medicine, Division of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA; The GOG Foundation, Philadelphia, PA, USA., Hietanen S; Department of Obstetrics & Gynecology, Turku University Hospital, Turku, Finland., McCormick CC; Legacy Medical Group-Gynecologic Oncology, Portland, OR, USA., Abadie-Lacourtoisie S; Department of Oncology, Institut de Cancérologie de l'Ouest, Site Paul Papin, Angers, France., O'Cearbhaill RE; The GOG Foundation, Philadelphia, PA, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY, USA., Heitz F; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany, and Department for Gynecology, Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin; Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin; and Berlin Institute of Health, Berlin, Germany., Moore RG; Division of Gynecologic Oncology, Wilmot Cancer Institute, Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA., Amit A; Gyneco-Oncology Unit, Rambam Health Care Campus, Haifa, and Israeli Society of Gynecologic Oncology (ISGO), Tel Aviv, Israel., Willmott LJ; Arizona Center for Cancer Care, Phoenix, AZ, USA., Pérez MR; Department of Medical Oncology, Reina Sofía University Hospital, Córdoba, and Grupo Español de Investigación en Cáncer ginecológicO (GEICO), Madrid, Spain., Burger RA; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA., Redondo A; Hospital Universitario La Paz - IdiPAZ, Madrid, Spain(.)., Chase DM; Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Romero I; Instituto Valenciano de Oncología, Valencia, Spain., Moore KN; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Vergote I; University Hospitals Leuven, Leuven Cancer Institute, and Belgium and Luxembourg Gynaecological Oncology Group (BGOG), Leuven, Belgium., Cloven N; Texas Oncology, Fort Worth, TX, USA., Haslund CA; Department of Oncology, Aalborg University Hospital, Aalborg, and Nordic Society of Gynaecological Oncology (NSGO), Copenhagen, Denmark., Graybill WS; Division of Gynecologic Oncology, Medical University of South Carolina, Charleston, SC, USA., Bergamini A; Obstetrics and Gynecology Unit, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milano, Italy., Berton D; Groupe d'Investigateurs National des Études des Cancers Ovariens et du sein (GINECO), Paris, and Institut de Cancérologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France., Braicu EI; Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Department of Gynecology, Charité, Universitätsmedizin Berlin, Berlin, Germany., Lim JT; GSK, Durham, NC, USA., Golembesky AK; GSK, Durham, NC, USA., Shtessel L; GSK, Upper Providence, PA, USA., Monk BJ; The GOG Foundation, Philadelphia, PA, USA; Florida Cancer Specialists & Research Institute, West Palm Beach, FL, USA., González-Martín A; Medical Oncology Department, Translational Oncology Group, CIMA, Universidad de Navarra, Cancer Center Clínica Universidad de Navarra, and Grupo Español de Investigación en Cáncer ginecológicO (GEICO), Madrid, Spain.
Source: Gynecologic oncology [Gynecol Oncol] 2026 Jul 01; Vol. 211, pp. 79-88. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Updated patient-reported outcomes and the effect of disease progression on health-related quality of life in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.
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  Data: <searchLink fieldCode="AU" term="%22Shahin+MS%22">Shahin MS</searchLink>; Division of Gynecologic Oncology, Penn State Hershey Medical Center, Hershey, PA, USA. Electronic address: mshahin@pennstatehealth.psu.edu.<br /><searchLink fieldCode="AU" term="%22Lorusso+D%22">Lorusso D</searchLink>; Fondazione Istituto Nazionale Tumori, and Multicenter Italian Trials in Ovarian Cancer and Gynecologic Malignancies (MITO), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Backes+FJ%22">Backes FJ</searchLink>; Division of Gynecologic Oncology, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Barretina-Ginesta+MP%22">Barretina-Ginesta MP</searchLink>; Medical Oncology Department, Institut Català d'Oncologia, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona University, Girona, and Grupo Español de Investigación en Cáncer ginecológicO (GEICO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22O'Malley+DM%22">O'Malley DM</searchLink>; The Ohio State University and The James Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Forget+F%22">Forget F</searchLink>; Department of Medical Oncology, Hôpital Vivalia De Libramont, Libramont-Chevigny, Belgium.<br /><searchLink fieldCode="AU" term="%22Pothuri+B%22">Pothuri B</searchLink>; Departments of Obstetrics/Gynecology and Medicine, Division of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA; The GOG Foundation, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hietanen+S%22">Hietanen S</searchLink>; Department of Obstetrics & Gynecology, Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22McCormick+CC%22">McCormick CC</searchLink>; Legacy Medical Group-Gynecologic Oncology, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Abadie-Lacourtoisie+S%22">Abadie-Lacourtoisie S</searchLink>; Department of Oncology, Institut de Cancérologie de l'Ouest, Site Paul Papin, Angers, France.<br /><searchLink fieldCode="AU" term="%22O'Cearbhaill+RE%22">O'Cearbhaill RE</searchLink>; The GOG Foundation, Philadelphia, PA, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Heitz+F%22">Heitz F</searchLink>; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany, and Department for Gynecology, Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin; Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin; and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Moore+RG%22">Moore RG</searchLink>; Division of Gynecologic Oncology, Wilmot Cancer Institute, Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Amit+A%22">Amit A</searchLink>; Gyneco-Oncology Unit, Rambam Health Care Campus, Haifa, and Israeli Society of Gynecologic Oncology (ISGO), Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Willmott+LJ%22">Willmott LJ</searchLink>; Arizona Center for Cancer Care, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Pérez+MR%22">Pérez MR</searchLink>; Department of Medical Oncology, Reina Sofía University Hospital, Córdoba, and Grupo Español de Investigación en Cáncer ginecológicO (GEICO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Burger+RA%22">Burger RA</searchLink>; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Redondo+A%22">Redondo A</searchLink>; Hospital Universitario La Paz - IdiPAZ, Madrid, Spain(.).<br /><searchLink fieldCode="AU" term="%22Chase+DM%22">Chase DM</searchLink>; Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Romero+I%22">Romero I</searchLink>; Instituto Valenciano de Oncología, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Moore+KN%22">Moore KN</searchLink>; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Vergote+I%22">Vergote I</searchLink>; University Hospitals Leuven, Leuven Cancer Institute, and Belgium and Luxembourg Gynaecological Oncology Group (BGOG), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Cloven+N%22">Cloven N</searchLink>; Texas Oncology, Fort Worth, TX, USA.<br /><searchLink fieldCode="AU" term="%22Haslund+CA%22">Haslund CA</searchLink>; Department of Oncology, Aalborg University Hospital, Aalborg, and Nordic Society of Gynaecological Oncology (NSGO), Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Graybill+WS%22">Graybill WS</searchLink>; Division of Gynecologic Oncology, Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Bergamini+A%22">Bergamini A</searchLink>; Obstetrics and Gynecology Unit, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Berton+D%22">Berton D</searchLink>; Groupe d'Investigateurs National des Études des Cancers Ovariens et du sein (GINECO), Paris, and Institut de Cancérologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France.<br /><searchLink fieldCode="AU" term="%22Braicu+EI%22">Braicu EI</searchLink>; Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Department of Gynecology, Charité, Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lim+JT%22">Lim JT</searchLink>; GSK, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Golembesky+AK%22">Golembesky AK</searchLink>; GSK, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Shtessel+L%22">Shtessel L</searchLink>; GSK, Upper Providence, PA, USA.<br /><searchLink fieldCode="AU" term="%22Monk+BJ%22">Monk BJ</searchLink>; The GOG Foundation, Philadelphia, PA, USA; Florida Cancer Specialists & Research Institute, West Palm Beach, FL, USA.<br /><searchLink fieldCode="AU" term="%22González-Martín+A%22">González-Martín A</searchLink>; Medical Oncology Department, Translational Oncology Group, CIMA, Universidad de Navarra, Cancer Center Clínica Universidad de Navarra, and Grupo Español de Investigación en Cáncer ginecológicO (GEICO), Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%220365304%22">Gynecologic oncology</searchLink> [Gynecol Oncol] 2026 Jul 01; Vol. 211, pp. 79-88. <i>Date of Electronic Publication: </i>2026 Jul 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0365304 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-6859 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200908258%22">00908258 </searchLink><i>NLM ISO Abbreviation: </i>Gynecol Oncol <i>Subsets: </i>MEDLINE
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