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Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primates.

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Title: Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primates.
Authors: Marlin R; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Centlivre M; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France., Bossevot L; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Gallouët AS; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Alexandre M; Vaccine Research Institute, Créteil, France; Université de Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, 33000, Bordeaux, France., Planas D; Vaccine Research Institute, Créteil, France; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, Paris, France., Cavarelli M; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Staropoli I; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, Paris, France., Gros W; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Surenaud M; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France., Fenwick C; Service of Immunology and Allergy, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Cardinaud S; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France., Galhaut M; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Zurawski S; Vaccine Research Institute, Créteil, France; Baylor Scott and White Research Institute and Inserm U955, Dallas, TX, United States of America., Magneron V; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Pintore L; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Hérate C; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Rameix Welti MA; National Reference Center for Respiratory Viruses, Molecular Mechanisms of Multiplication of Pneumoviruses Unit, Institut Pasteur, Université Paris Cité, Paris, France; Molecular Mechanisms of Multiplication of Pneumoviruses, Université Paris-Saclay, Université de Versailles St. Quentin, UMR 1173 (2I), INSERM, Assistance Publique des Hôpitaux de Paris, Paris, France., Mazet P; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Contreras V; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Relouzat F; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Dereuddre-Bosquet N; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Pantaleo G; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France; Swiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland., Thiébaut R; Vaccine Research Institute, Créteil, France; Université de Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, 33000, Bordeaux, France; CHU Bordeaux, Department of Medical information, Bordeaux, France., Prague M; Vaccine Research Institute, Créteil, France; Université de Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, 33000, Bordeaux, France., Schwartz O; Vaccine Research Institute, Créteil, France; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, Paris, France., Zurawski G; Vaccine Research Institute, Créteil, France; Baylor Scott and White Research Institute and Inserm U955, Dallas, TX, United States of America., Godot V; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France., Le Grand R; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France. Electronic address: roger.le-grand@cea.fr., Lévy Y; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France; AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique et Maladies Infectieuses, Créteil, France. Electronic address: yves.levy@inserm.fr.
Source: EBioMedicine [EBioMedicine] 2026 Jul; Vol. 129, pp. 106361. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primates.
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  Data: <searchLink fieldCode="AU" term="%22Marlin+R%22">Marlin R</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Centlivre+M%22">Centlivre M</searchLink>; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Bossevot+L%22">Bossevot L</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Gallouët+AS%22">Gallouët AS</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Alexandre+M%22">Alexandre M</searchLink>; Vaccine Research Institute, Créteil, France; Université de Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, 33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Planas+D%22">Planas D</searchLink>; Vaccine Research Institute, Créteil, France; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cavarelli+M%22">Cavarelli M</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Staropoli+I%22">Staropoli I</searchLink>; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gros+W%22">Gros W</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Surenaud+M%22">Surenaud M</searchLink>; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Fenwick+C%22">Fenwick C</searchLink>; Service of Immunology and Allergy, Lausanne University Hospital (CHUV), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cardinaud+S%22">Cardinaud S</searchLink>; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Galhaut+M%22">Galhaut M</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Zurawski+S%22">Zurawski S</searchLink>; Vaccine Research Institute, Créteil, France; Baylor Scott and White Research Institute and Inserm U955, Dallas, TX, United States of America.<br /><searchLink fieldCode="AU" term="%22Magneron+V%22">Magneron V</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Pintore+L%22">Pintore L</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Hérate+C%22">Hérate C</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Rameix+Welti+MA%22">Rameix Welti MA</searchLink>; National Reference Center for Respiratory Viruses, Molecular Mechanisms of Multiplication of Pneumoviruses Unit, Institut Pasteur, Université Paris Cité, Paris, France; Molecular Mechanisms of Multiplication of Pneumoviruses, Université Paris-Saclay, Université de Versailles St. Quentin, UMR 1173 (2I), INSERM, Assistance Publique des Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mazet+P%22">Mazet P</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Contreras+V%22">Contreras V</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Relouzat+F%22">Relouzat F</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Dereuddre-Bosquet+N%22">Dereuddre-Bosquet N</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Pantaleo+G%22">Pantaleo G</searchLink>; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France; Swiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thiébaut+R%22">Thiébaut R</searchLink>; Vaccine Research Institute, Créteil, France; Université de Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, 33000, Bordeaux, France; CHU Bordeaux, Department of Medical information, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Prague+M%22">Prague M</searchLink>; Vaccine Research Institute, Créteil, France; Université de Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, 33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Schwartz+O%22">Schwartz O</searchLink>; Vaccine Research Institute, Créteil, France; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Zurawski+G%22">Zurawski G</searchLink>; Vaccine Research Institute, Créteil, France; Baylor Scott and White Research Institute and Inserm U955, Dallas, TX, United States of America.<br /><searchLink fieldCode="AU" term="%22Godot+V%22">Godot V</searchLink>; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Le+Grand+R%22">Le Grand R</searchLink>; Université Paris-Saclay, Inserm, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184); Fontenay-aux-Roses & Le Kremlin-Bicêtre, France. Electronic address: roger.le-grand@cea.fr.<br /><searchLink fieldCode="AU" term="%22Lévy+Y%22">Lévy Y</searchLink>; Vaccine Research Institute, Créteil, France; Inserm U955, Equipe 16, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France; AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique et Maladies Infectieuses, Créteil, France. Electronic address: yves.levy@inserm.fr.
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