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Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

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Title: Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.
Authors: Zhou Z; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: zinan.zhou@childrens.harvard.edu., Luquette LJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Electronic address: lovelace_luquette@hms.harvard.edu., Dong G; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Bioinformatics and Integrative Genomics Program, Harvard Medical School, Boston, MA, USA., Kim J; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea., Ku J; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Kim K; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Ramesh N; Department of Neurology, Sean M. Healey & AMG Center for ALS, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Bae M; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Caplin A; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Shao DD; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA., Sahile B; Program in Neuroscience, Harvard Medical School, Boston, MA, USA., Essuman K; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA., Goodman E; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA., Miller MB; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Division of Neuropathology, Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA., Huang AY; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Electronic address: peter_park@hms.harvard.edu., Lagier-Tourenne C; Department of Neurology, Sean M. Healey & AMG Center for ALS, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: clagier-tourenne@mgh.harvard.edu., Lee EA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: ealee@childrens.harvard.edu., Walsh CA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA. Electronic address: christopher.walsh@childrens.harvard.edu.
Source: Cell [Cell] 2026 Jul 01. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 42385702
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PubType: Academic Journal
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  Data: Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: zinan.zhou@childrens.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Luquette+LJ%22">Luquette LJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Electronic address: lovelace_luquette@hms.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Dong+G%22">Dong G</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Bioinformatics and Integrative Genomics Program, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Ku+J%22">Ku J</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ramesh+N%22">Ramesh N</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bae+M%22">Bae M</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Caplin+A%22">Caplin A</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shao+DD%22">Shao DD</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sahile+B%22">Sahile B</searchLink>; Program in Neuroscience, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Essuman+K%22">Essuman K</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goodman+E%22">Goodman E</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+MB%22">Miller MB</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Division of Neuropathology, Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+AY%22">Huang AY</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nathan+WJ%22">Nathan WJ</searchLink>; Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nussenzweig+A%22">Nussenzweig A</searchLink>; Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Park+PJ%22">Park PJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Electronic address: peter_park@hms.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Lagier-Tourenne+C%22">Lagier-Tourenne C</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: clagier-tourenne@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Lee+EA%22">Lee EA</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: ealee@childrens.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Walsh+CA%22">Walsh CA</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA. Electronic address: christopher.walsh@childrens.harvard.edu.
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        Value: 10.1016/j.cell.2026.06.013
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