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IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial.

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Title: IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial.
Authors: Bunse L; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. l.bunse@dkfz.de.; Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany. l.bunse@dkfz.de.; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany. l.bunse@dkfz.de.; Hertie Network of Excellence in Clinical Neuroscience, Tübingen, Germany. l.bunse@dkfz.de.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. l.bunse@dkfz.de.; Cluster of Excellence SynthImmune (EXC 3018/1) 'Engineering Immune function with Synthetic Biology', University of Heidelberg, Mannheim, Germany. l.bunse@dkfz.de., Lindner K; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany.; Cluster of Excellence SynthImmune (EXC 3018/1) 'Engineering Immune function with Synthetic Biology', University of Heidelberg, Mannheim, Germany.; Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Wick A; Neurology Clinic and European Center for Neurooncology (EZN), Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Freitag A; NCT Trial Management and Services, NCT, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Lanz LM; NCT Trial Management and Services, NCT, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Edelmann D; NCT Trial Management and Services, NCT, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Suwala A; Department of Neuropathology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Breckwoldt MO; Department of Neuroradiology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Harting I; Department of Neuroradiology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Sahm F; Department of Neuropathology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.; DKTK CCU Neuropathology, DKFZ, Heidelberg, Germany., Schlenk RF; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany.; NCT Trial Management and Services, NCT, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Schmitt A; Department of Internal Medicine V, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Schnell O; Neurosurgery Clinic, University Hospital Erlangen, Erlangen, Germany., Hense J; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Misch M; Department of Neurosurgery, Charité Medical Center, University of Berlin, Berlin, Germany., Krex D; Technische Universität Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, Department of Neurosurgery, Dresden, Germany., Denk M; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Tübingen, Tübingen, Germany., Walz J; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Tübingen, Tübingen, Germany., Steinbach JP; Dr. Senckenberg Institute of Neurooncology, Frankfurt, Germany., von Deimling A; Department of Neuropathology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.; DKTK CCU Neuropathology, DKFZ, Heidelberg, Germany., Schmitt M; Department of Internal Medicine V, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Bunse T; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany.; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany., Tabatabai G; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Tübingen, Tübingen, Germany.; Department of Neurology and Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.; Center for Neuro-Oncology, CCC Tübingen-Stuttgart in CCC-SW, Tübingen, Germany., Bendszus M; Department of Neuroradiology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Poschke I; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany.; Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Wick W; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany.; Hertie Network of Excellence in Clinical Neuroscience, Tübingen, Germany.; Neurology Clinic and European Center for Neurooncology (EZN), Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.; DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany., Platten M; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.platten@dkfz.de.; Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany. m.platten@dkfz.de.; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany. m.platten@dkfz.de.; Hertie Network of Excellence in Clinical Neuroscience, Tübingen, Germany. m.platten@dkfz.de.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. m.platten@dkfz.de.; Cluster of Excellence SynthImmune (EXC 3018/1) 'Engineering Immune function with Synthetic Biology', University of Heidelberg, Mannheim, Germany. m.platten@dkfz.de.; Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany. m.platten@dkfz.de.; Helmholtz Institute for Translational Oncology (HI-TRON) Mainz, German Cancer Research Center, Mainz, Germany. m.platten@dkfz.de.
Source: Nature cancer [Nat Cancer] 2026 Jul 01. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Bunse+L%22">Bunse L</searchLink>; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. l.bunse@dkfz.de.; Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany. l.bunse@dkfz.de.; German Cancer Consortium (DKTK), DKFZ, Core Center, Heidelberg, Germany. l.bunse@dkfz.de.; Hertie Network of Excellence in Clinical Neuroscience, Tübingen, Germany. l.bunse@dkfz.de.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. l.bunse@dkfz.de.; Cluster of Excellence SynthImmune (EXC 3018/1) 'Engineering Immune function with Synthetic Biology', University of Heidelberg, Mannheim, Germany. l.bunse@dkfz.de.<br /><searchLink fieldCode="AU" term="%22Lindner+K%22">Lindner K</searchLink>; DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; 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