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Blood-based circular RNAs for early diagnosis of Alzheimer's disease.

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Title: Blood-based circular RNAs for early diagnosis of Alzheimer's disease.
Authors: Phillips B; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Sanford J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Janve VA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Liu M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Johnson M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Gong K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Bergmann K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Lowery J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Flynn A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Brock W; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Montejo BS; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Sykora N; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Budde J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Mellios N; Circular Genomics, San Diego, CA, USA., Papageorgiou G; Circular Genomics, San Diego, CA, USA., Sperling RA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Buckley RF; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia., Seto M; Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Perlmutter JS; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Kotzbauer PT; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Perrin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.
Source: Nature medicine [Nat Med] 2026 Jul 01. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Blood-based circular RNAs for early diagnosis of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Phillips+B%22">Phillips B</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sanford+J%22">Sanford J</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Janve+VA%22">Janve VA</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+M%22">Johnson M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gong+K%22">Gong K</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bergmann+K%22">Bergmann K</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lowery+J%22">Lowery J</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Flynn+A%22">Flynn A</searchLink>; 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Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Mellios+N%22">Mellios N</searchLink>; Circular Genomics, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Papageorgiou+G%22">Papageorgiou G</searchLink>; Circular Genomics, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sperling+RA%22">Sperling RA</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Buckley+RF%22">Buckley RF</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Seto+M%22">Seto M</searchLink>; Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Perlmutter+JS%22">Perlmutter JS</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Kotzbauer+PT%22">Kotzbauer PT</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Perrin+RJ%22">Perrin RJ</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Hohman+TJ%22">Hohman TJ</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ibanez+L%22">Ibanez L</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.
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