Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB1 and 5-HT1A receptor signaling.
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| Title: | Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB |
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| Authors: | Acunha RM; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Domingues BRR; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Barros N; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Medeiros P; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Psychology, Ribeirão Preto School of Philosophy, Science and Literature of the University of São Paulo, Ribeirão Preto, Brazil., Hallak JEC; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, National Institute of Science and Technology in Translational Medicine, CNPq/FAPESP/CAPES, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Coimbra NC; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, FMRP-USP, Ribeirão Preto (SP), Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Psychology, Ribeirão Preto School of Philosophy, Science and Literature of the University of São Paulo, Ribeirão Preto, Brazil., Maione S; Department of Experimental Medicine, University of Campania ''Luigi Vanvitelli'', Naples, 80138, Italy., de Freitas RL; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil. rlfreitas@usp.br.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil. rlfreitas@usp.br.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil. rlfreitas@usp.br.; Institute of Natural Sciences, Federal University of Alfenas (UNIFAL-MG), Minas Gerais (MG), Str. Gabriel Monteiro da Silva, 700, Alfenas, 37130-000, Brasil. rlfreitas@usp.br.; Laboratory of Neurosciences of Pain & Emotions and Multi-User Center of Neuroelectrophysiology, Department of Neuroscience and Behavioral Science, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, Ribeirão Preto,, São Paulo, 3900, Brasil. rlfreitas@usp.br. |
| Source: | Psychopharmacology [Psychopharmacology (Berl)] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42390818 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<subscript>1</subscript> and 5-HT<subscript>1A</subscript> receptor signaling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Acunha+RM%22">Acunha RM</searchLink>; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.<br /><searchLink fieldCode="AU" term="%22Domingues+BRR%22">Domingues BRR</searchLink>; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.<br /><searchLink fieldCode="AU" term="%22Barros+N%22">Barros N</searchLink>; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.<br /><searchLink fieldCode="AU" term="%22Medeiros+P%22">Medeiros P</searchLink>; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Psychology, Ribeirão Preto School of Philosophy, Science and Literature of the University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Hallak+JEC%22">Hallak JEC</searchLink>; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, National Institute of Science and Technology in Translational Medicine, CNPq/FAPESP/CAPES, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.<br /><searchLink fieldCode="AU" term="%22Coimbra+NC%22">Coimbra NC</searchLink>; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, FMRP-USP, Ribeirão Preto (SP), Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Psychology, Ribeirão Preto School of Philosophy, Science and Literature of the University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Maione+S%22">Maione S</searchLink>; Department of Experimental Medicine, University of Campania ''Luigi Vanvitelli'', Naples, 80138, Italy.<br /><searchLink fieldCode="AU" term="%22de+Freitas+RL%22">de Freitas RL</searchLink>; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil. rlfreitas@usp.br.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil. rlfreitas@usp.br.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil. rlfreitas@usp.br.; Institute of Natural Sciences, Federal University of Alfenas (UNIFAL-MG), Minas Gerais (MG), Str. Gabriel Monteiro da Silva, 700, Alfenas, 37130-000, Brasil. rlfreitas@usp.br.; Laboratory of Neurosciences of Pain & Emotions and Multi-User Center of Neuroelectrophysiology, Department of Neuroscience and Behavioral Science, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, Ribeirão Preto,, São Paulo, 3900, Brasil. rlfreitas@usp.br. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227608025%22">Psychopharmacology</searchLink> [Psychopharmacology (Berl)] 2026 Jul 02. <i>Date of Electronic Publication: </i>2026 Jul 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>7608025 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-2072 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200333158%22">00333158 </searchLink><i>NLM ISO Abbreviation: </i>Psychopharmacology (Berl) <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42390818 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-026-07116-6 Languages: – Code: eng Text: English Titles: – TitleFull: Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB1 and 5-HT1A receptor signaling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Acunha RM – PersonEntity: Name: NameFull: Domingues BRR – PersonEntity: Name: NameFull: Barros N – PersonEntity: Name: NameFull: Medeiros P – PersonEntity: Name: NameFull: Hallak JEC – PersonEntity: Name: NameFull: Coimbra NC – PersonEntity: Name: NameFull: Maione S – PersonEntity: Name: NameFull: de Freitas RL IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 07 Text: 2026 Jul 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-2072 Titles: – TitleFull: Psychopharmacology Type: main |
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