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Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB1 and 5-HT1A receptor signaling.

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Title: Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB1 and 5-HT1A receptor signaling.
Authors: Acunha RM; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Domingues BRR; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Barros N; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Medeiros P; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Psychology, Ribeirão Preto School of Philosophy, Science and Literature of the University of São Paulo, Ribeirão Preto, Brazil., Hallak JEC; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Neurosciences and Behavioral Sciences, National Institute of Science and Technology in Translational Medicine, CNPq/FAPESP/CAPES, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil., Coimbra NC; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil.; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, FMRP-USP, Ribeirão Preto (SP), Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900, Brasil.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil.; Department of Psychology, Ribeirão Preto School of Philosophy, Science and Literature of the University of São Paulo, Ribeirão Preto, Brazil., Maione S; Department of Experimental Medicine, University of Campania ''Luigi Vanvitelli'', Naples, 80138, Italy., de Freitas RL; Multi-User Center of Neuroelectrophysiology, Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, São Paulo, Ribeirão Preto, 3900, Brasil. rlfreitas@usp.br.; Laboratory of Neurosciences of Pain & Emotions, Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil. rlfreitas@usp.br.; Department of Neurosciences and Behavioral Sciences, FMRP-USP, Av. Bandeirantes, Ribeirão Preto, São Paulo, 3900, Brasil. rlfreitas@usp.br.; Institute of Natural Sciences, Federal University of Alfenas (UNIFAL-MG), Minas Gerais (MG), Str. Gabriel Monteiro da Silva, 700, Alfenas, 37130-000, Brasil. rlfreitas@usp.br.; Laboratory of Neurosciences of Pain & Emotions and Multi-User Center of Neuroelectrophysiology, Department of Neuroscience and Behavioral Science, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, Ribeirão Preto,, São Paulo, 3900, Brasil. rlfreitas@usp.br.
Source: Psychopharmacology [Psychopharmacology (Berl)] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-2072
DOI:10.1007/s00213-026-07116-6