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De novo direct sequencing of small therapeutic RNAs by layer-by-layer intensity-resolved mass spectrometry.

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Title: De novo direct sequencing of small therapeutic RNAs by layer-by-layer intensity-resolved mass spectrometry.
Authors: Lin S; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States., Jiang S; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States., Tang L; Department of Biological and Chemical Sciences, New York Institute of Technology, New York, NY 10023, United States., Kumbhakonam SK; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States., Dingman JC; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States., Lee JY; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States., Yang R; DirectSeq Biosciences, Inc., Albany, NY 12222, United States., Frudakis T; DirectSeq Biosciences, Inc., Albany, NY 12222, United States., Kirchner M; Department of Biological and Chemical Sciences, New York Institute of Technology, New York, NY 10023, United States., Xu S; Department of Biological and Chemical Sciences, New York Institute of Technology, New York, NY 10023, United States., Tao C; Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, Columbia University, New York, NY 10027, United States., Wang X; Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, Columbia University, New York, NY 10027, United States., Russo JJ; Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, Columbia University, New York, NY 10027, United States., Zhang X; Molecular Medicine Program, Department of Human Genetics, and Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, United States., Chen Q; Molecular Medicine Program, Department of Human Genetics, and Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, United States., Zhang S; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Jun 22; Vol. 54 (12).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+S%22">Jiang S</searchLink>; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; Department of Biological and Chemical Sciences, New York Institute of Technology, New York, NY 10023, United States.<br /><searchLink fieldCode="AU" term="%22Kumbhakonam+SK%22">Kumbhakonam SK</searchLink>; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Dingman+JC%22">Dingman JC</searchLink>; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; DirectSeq Biosciences, Inc., Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Frudakis+T%22">Frudakis T</searchLink>; DirectSeq Biosciences, Inc., Albany, NY 12222, United States.<br /><searchLink fieldCode="AU" term="%22Kirchner+M%22">Kirchner M</searchLink>; Department of Biological and Chemical Sciences, New York Institute of Technology, New York, NY 10023, United States.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Biological and Chemical Sciences, New York Institute of Technology, New York, NY 10023, United States.<br /><searchLink fieldCode="AU" term="%22Tao+C%22">Tao C</searchLink>; Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, Columbia University, New York, NY 10027, United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, Columbia University, New York, NY 10027, United States.<br /><searchLink fieldCode="AU" term="%22Russo+JJ%22">Russo JJ</searchLink>; Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, Columbia University, New York, NY 10027, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Molecular Medicine Program, Department of Human Genetics, and Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, United States.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Molecular Medicine Program, Department of Human Genetics, and Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, United States.
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              Text: 2026 Jun 22
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