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Zonated mechanosensing by PIEZO1 controls liver regeneration.

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Title: Zonated mechanosensing by PIEZO1 controls liver regeneration.
Authors: Zhang Y; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Sun Y; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Xu G; Department of Engineering Mechanics, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, China., Wu Y; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Shi Z; Department of Engineering Mechanics, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, China., Chang Z; Department of Engineering Mechanics, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, China., Liu J; Techshake Biotechnology Co., Ltd., Xi'an, Shaanxi, China., Pang K; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Liu S; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Wang H; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Rong W; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Shao Z; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Liu X; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., He Y; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Yan Y; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Zhou B; CAS CEMCS-CUHK Joint Laboratory, New Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China., Yuan Z; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Zhang XF; Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Offermanns S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany., Wang S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Source: Science (New York, N.Y.) [Science] 2026 Jul 02; Vol. 393 (6806), pp. eaef0825. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; Department of Engineering Mechanics, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Engineering Mechanics, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Chang+Z%22">Chang Z</searchLink>; Department of Engineering Mechanics, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Techshake Biotechnology Co., Ltd., Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Pang+K%22">Pang K</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Rong+W%22">Rong W</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Shao+Z%22">Shao Z</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Zhou+B%22">Zhou B</searchLink>; CAS CEMCS-CUHK Joint Laboratory, New Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Z%22">Yuan Z</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XF%22">Zhang XF</searchLink>; Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Offermanns+S%22">Offermanns S</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jul 02; Vol. 393 (6806), pp. eaef0825. <i>Date of Electronic Publication: </i>2026 Jul 02.
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              Text: 2026 Jul 02
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