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HER2DX genomic assay in HER2-positive early breast cancer treated with trastuzumab and pertuzumab: A correlative analysis from a real-world cohort.

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Title: HER2DX genomic assay in HER2-positive early breast cancer treated with trastuzumab and pertuzumab: A correlative analysis from a real-world cohort.
Authors: de Castro BA; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain. Electronic address: Beatriz.alonso.de.castro@sergas.es., Cobo S; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain., Pena MA; Universidade de Santiago de Compostela. Praza do Obradoiro, s/n, Santiago de Compostela, 15782, Spain; Centro de Investigación e Tecnoloxía Matemática de Galicia, CITMAga. Edificio Instituto Investigaciones Tecnológicas, planta -1. Constantino Candeira s/n., Campus Vida, Santiago de Compostela, 15782, Spain., Malillos JP; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain., Rendo CR; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain., López EP; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain., Castillo O; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain., Sirenko V; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain., Aguirre A; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain., Blasco P; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain., Martínez LC; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain., Galván P; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain; Reveal Genomics, Villarroel, 170, Barcelona, 08036, Spain., Sanfeliu E; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Pathology Department, Clinic Hospital Barcelona, Villarroel, 170, Barcelona, 08036, Spain., Nieves PS; Universidade de Santiago de Compostela. Praza do Obradoiro, s/n, Santiago de Compostela, 15782, Spain; Centro de Investigación e Tecnoloxía Matemática de Galicia, CITMAga. Edificio Instituto Investigaciones Tecnológicas, planta -1. Constantino Candeira s/n., Campus Vida, Santiago de Compostela, 15782, Spain., López ÁC; Pathology Department, A Coruña University Hospital, As Xubias, 84, A Coruña, 15006, Spain., Prat A; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain; Centro de Investigación e Tecnoloxía Matemática de Galicia, CITMAga. Edificio Instituto Investigaciones Tecnológicas, planta -1. Constantino Candeira s/n., Campus Vida, Santiago de Compostela, 15782, Spain; Department of Medicine, University of Barcelona. Casanova, 143, Barcelona, 08007, Spain., Brasó-Maristany F; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain; Reveal Genomics, Villarroel, 170, Barcelona, 08036, Spain., Novoa SA; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain.
Source: Breast (Edinburgh, Scotland) [Breast] 2026 Jun 23; Vol. 89, pp. 104849. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HER2DX genomic assay in HER2-positive early breast cancer treated with trastuzumab and pertuzumab: A correlative analysis from a real-world cohort.
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  Data: <searchLink fieldCode="AU" term="%22de+Castro+BA%22">de Castro BA</searchLink>; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain. Electronic address: Beatriz.alonso.de.castro@sergas.es.<br /><searchLink fieldCode="AU" term="%22Cobo+S%22">Cobo S</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Pena+MA%22">Pena MA</searchLink>; Universidade de Santiago de Compostela. Praza do Obradoiro, s/n, Santiago de Compostela, 15782, Spain; Centro de Investigación e Tecnoloxía Matemática de Galicia, CITMAga. Edificio Instituto Investigaciones Tecnológicas, planta -1. Constantino Candeira s/n., Campus Vida, Santiago de Compostela, 15782, Spain.<br /><searchLink fieldCode="AU" term="%22Malillos+JP%22">Malillos JP</searchLink>; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain.<br /><searchLink fieldCode="AU" term="%22Rendo+CR%22">Rendo CR</searchLink>; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain.<br /><searchLink fieldCode="AU" term="%22López+EP%22">López EP</searchLink>; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain.<br /><searchLink fieldCode="AU" term="%22Castillo+O%22">Castillo O</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Sirenko+V%22">Sirenko V</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Aguirre+A%22">Aguirre A</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Blasco+P%22">Blasco P</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez+LC%22">Martínez LC</searchLink>; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain.<br /><searchLink fieldCode="AU" term="%22Galván+P%22">Galván P</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain; Reveal Genomics, Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Sanfeliu+E%22">Sanfeliu E</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Pathology Department, Clinic Hospital Barcelona, Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Nieves+PS%22">Nieves PS</searchLink>; Universidade de Santiago de Compostela. Praza do Obradoiro, s/n, Santiago de Compostela, 15782, Spain; Centro de Investigación e Tecnoloxía Matemática de Galicia, CITMAga. Edificio Instituto Investigaciones Tecnológicas, planta -1. Constantino Candeira s/n., Campus Vida, Santiago de Compostela, 15782, Spain.<br /><searchLink fieldCode="AU" term="%22López+ÁC%22">López ÁC</searchLink>; Pathology Department, A Coruña University Hospital, As Xubias, 84, A Coruña, 15006, Spain.<br /><searchLink fieldCode="AU" term="%22Prat+A%22">Prat A</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain; Centro de Investigación e Tecnoloxía Matemática de Galicia, CITMAga. Edificio Instituto Investigaciones Tecnológicas, planta -1. Constantino Candeira s/n., Campus Vida, Santiago de Compostela, 15782, Spain; Department of Medicine, University of Barcelona. Casanova, 143, Barcelona, 08007, Spain.<br /><searchLink fieldCode="AU" term="%22Brasó-Maristany+F%22">Brasó-Maristany F</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors lab, IDIBAPS. Roselló, 149-153, Barcelona, 08036, Spain; Clínic Barcelona Comprehensive Cancer Center, Clínic Hospital Barcelona, Barcelona, Calle Villarroel, 170, Barcelona, 08036, Spain; Reveal Genomics, Villarroel, 170, Barcelona, 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Novoa+SA%22">Novoa SA</searchLink>; Department of Medical Oncology, A Coruña University Hospital. As Xubias, 84, A Coruña, 15006, Spain; Institute for Biomedical Research of A Coruña, INIBIC, As Xubias, 84, A Coruña, 15006, Spain.
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  Data: <searchLink fieldCode="JN" term="%229213011%22">Breast (Edinburgh, Scotland)</searchLink> [Breast] 2026 Jun 23; Vol. 89, pp. 104849. <i>Date of Electronic Publication: </i>2026 Jun 23.
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