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Towards use of Patient-informed Relevant Outcomes (PRO) in trials of bloodstream infections: a mixed-methods study protocol (BALANCE+PRO).

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Title: Towards use of Patient-informed Relevant Outcomes (PRO) in trials of bloodstream infections: a mixed-methods study protocol (BALANCE+PRO).
Authors: Somayaji R; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada rsomayaj@ucalgary.ca.; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada., Haldane V; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada., Fowler R; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Krewulak KD; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Foster N; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Longmore S; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Ong SWX; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.; Melbourne Center for Clinical Trials, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Tong S; Department of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.; Melbourne Center for Clinical Trials, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Rogers BA; Melbourne Center for Clinical Trials, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Center for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia., Burry L; Departments of Pharmacy and Medicine, Sinai Health, University of Toronto, Toronto, Ontario, Canada., Kissel K; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Paterson DL; ADVANCE-ID Network, National University Singapore Saw Swee Hock School of Public Health, Singapore., Daneman N; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Fiest K; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.
Source: BMJ open [BMJ Open] 2026 Jul 02; Vol. 16 (7), pp. e119849. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Towards use of Patient-informed Relevant Outcomes (PRO) in trials of bloodstream infections: a mixed-methods study protocol (BALANCE+PRO).
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  Data: <searchLink fieldCode="AU" term="%22Somayaji+R%22">Somayaji R</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada rsomayaj@ucalgary.ca.; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Haldane+V%22">Haldane V</searchLink>; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Fowler+R%22">Fowler R</searchLink>; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Krewulak+KD%22">Krewulak KD</searchLink>; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Foster+N%22">Foster N</searchLink>; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Longmore+S%22">Longmore S</searchLink>; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ong+SWX%22">Ong SWX</searchLink>; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.; Melbourne Center for Clinical Trials, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tong+S%22">Tong S</searchLink>; Department of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.; Melbourne Center for Clinical Trials, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rogers+BA%22">Rogers BA</searchLink>; Melbourne Center for Clinical Trials, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Center for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Burry+L%22">Burry L</searchLink>; Departments of Pharmacy and Medicine, Sinai Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kissel+K%22">Kissel K</searchLink>; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Paterson+DL%22">Paterson DL</searchLink>; ADVANCE-ID Network, National University Singapore Saw Swee Hock School of Public Health, Singapore.<br /><searchLink fieldCode="AU" term="%22Daneman+N%22">Daneman N</searchLink>; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fiest+K%22">Fiest K</searchLink>; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.
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              Text: 2026 Jul 02
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