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Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.

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Title: Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.
Authors: Devenish SO; UCL Queen Square Institute of Neurology, University College London, London, UK. s.o.devenish@gmail.com., Patel SD; UCL Queen Square Institute of Neurology, University College London, London, UK., Ussingkær LV; UCL Queen Square Institute of Neurology, University College London, London, UK., Almeida Silva LF; UCL Queen Square Institute of Neurology, University College London, London, UK., Goff O; UCL Queen Square Institute of Neurology, University College London, London, UK., Richardson A; UCL Queen Square Institute of Neurology, University College London, London, UK., Mobbs JI; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Venugopal H; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia. David.Thal@monash.edu.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia. David.Thal@monash.edu., Kullmann DM; UCL Queen Square Institute of Neurology, University College London, London, UK. d.kullmann@ucl.ac.uk.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jul 03; Vol. 11 (1). Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Devenish+SO%22">Devenish SO</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK. s.o.devenish@gmail.com.<br /><searchLink fieldCode="AU" term="%22Patel+SD%22">Patel SD</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ussingkær+LV%22">Ussingkær LV</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Almeida+Silva+LF%22">Almeida Silva LF</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Goff+O%22">Goff O</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Richardson+A%22">Richardson A</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mobbs+JI%22">Mobbs JI</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Venugopal+H%22">Venugopal H</searchLink>; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Thal+DM%22">Thal DM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia. David.Thal@monash.edu.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia. David.Thal@monash.edu.<br /><searchLink fieldCode="AU" term="%22Kullmann+DM%22">Kullmann DM</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, UK. d.kullmann@ucl.ac.uk.
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              Text: 2026 Jul 03
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