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VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair.

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Title: VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair.
Authors: Adeosun OA; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Schröer C; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Südhoff E; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Bergenthal F; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Sommer K; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Döffinger E; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Fiedler B; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Hilderink A; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Lehmann AK; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Pohle LS; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Korneev SM; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Fröhlich F; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Bioanalytical Chemistry Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany., Maeda K; Cell Death and Metabolism Group, Center for Autophagy, Recycling and Disease, Danish Cancer Institute, Copenhagen, Denmark., Kurre R; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Biophysics Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany., Holtmannspötter M; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Biophysics Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany., Esch BM; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Bioanalytical Chemistry Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany., Holthuis JCM; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany. holthuis@uos.de.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany. holthuis@uos.de.
Source: Nature communications [Nat Commun] 2026 Jul 02; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair.
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  Data: <searchLink fieldCode="AU" term="%22Adeosun+OA%22">Adeosun OA</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Schröer+C%22">Schröer C</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Südhoff+E%22">Südhoff E</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Bergenthal+F%22">Bergenthal F</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Sommer+K%22">Sommer K</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Döffinger+E%22">Döffinger E</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Fiedler+B%22">Fiedler B</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Hilderink+A%22">Hilderink A</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+AK%22">Lehmann AK</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Pohle+LS%22">Pohle LS</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Korneev+SM%22">Korneev SM</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Fröhlich+F%22">Fröhlich F</searchLink>; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Bioanalytical Chemistry Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Maeda+K%22">Maeda K</searchLink>; Cell Death and Metabolism Group, Center for Autophagy, Recycling and Disease, Danish Cancer Institute, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kurre+R%22">Kurre R</searchLink>; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Biophysics Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Holtmannspötter+M%22">Holtmannspötter M</searchLink>; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Biophysics Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Esch+BM%22">Esch BM</searchLink>; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.; Bioanalytical Chemistry Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Holthuis+JCM%22">Holthuis JCM</searchLink>; Molecular Cell Biology Section, Department of Biology/Chemistry, Osnabrück University, Osnabrück, Germany. holthuis@uos.de.; Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany. holthuis@uos.de.
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