Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

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Title: Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.
Authors: Mufford MS; Division of Human Genetics, School of Pathology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa. mary.mufford@wits.ac.za.; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. mary.mufford@wits.ac.za., van der Meer D; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands., Baird CL; Brain Imaging Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Department of Psychology, Pennsylvania State University, University Park, PA, USA., Sun D; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA., LaBar KS; Center for Cognitive Neuroscience, Duke University, Durham, NC, USA., Ramesar R; South African Medical Research Council Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Hussain A; Brain Imaging Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA., Abdallah CG; Department of Psychiatry, Baylor college of medicine, Houston, TX, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Andrew E; Department of Psychology, University of Sydney, Westmead, NSW, Australia., Averill CL; Department of Psychiatry, Baylor college of medicine, Houston, TX, USA.; Core for Advanced MRI (CAMRI), Baylor College of Medicine, Houston, TX, USA., Baker JT; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.; Massachusetts General Brigham Department of Psychiatry, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Baugh LA; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Sioux Falls VA Health Care System, Sioux Falls, SD, USA., Blackford JU; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA., Bomyea J; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.; VA San Diego Center of Excellence for Stress and Mental Health, San Diego, CA, USA., Bryant RA; School of Psychology, University of New South Wales, Sydney, NSW, Australia.; Black Dog Institute, Sydney, Australia., Ching CRK; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Choi K; Health Services Research Center, University of California San Diego, San Diego, CA, USA., Cotton AS; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Daniels JK; Department of Clinical Psychology, University of Groningen, Groningen, Netherlands.; Traumacentrum Beilen, GGZ Drenthe, Beilen, Netherlands., Davenport ND; Research, Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA., Davidson RJ; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA., De Bellis MD; Brain Imaging Analysis Center, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA., Dennis EL; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA., Densmore M; Department of Psychiatry, Western University, London, ON, Canada., deRoon-Cassini TA; Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.; Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA., Disner SG; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.; Mental Health Integrated Care Community, Minneapolis VA Health Care System, Minneapolis, MN, USA., du Plessis S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council on the Genomics of Brain Disorders, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Etkin A; Alto Neuroscience, Inc, Mountain View, CA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Fercho KA; Federal Aviation Administration, Washington, D.C., USA., Fitzgerald J; Department of Psychology, Marquette University, Milwaukee, WI, USA., Geuze E; Brain Research & Innovation Centre, Ministry of Defence, Utrecht, Netherlands.; Department of Psychiatry, Utrecht University Medical Center, Utrecht, Netherlands., Gordon EM; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Grupe DW; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA., Harpaz-Rotem I; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA., Russel CC; Brain Imaging Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA., Herzog JI; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Hofmann D; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Ipser J; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Jovanovic T; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA., Kaufman ML; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Women's Mental Health, McLean Hospital, Harvard University, Belmont, MA, USA., Koch SBJ; Department of Psychiatry, University of Amsterdam, Amsterdam, Netherlands.; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands., Koerte IK; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, MA, USA.; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany., Korgaonkar MS; Brain Dynamics Centre, Westmead Institute of Medical Research, Sydney, NSW, Australia.; Discipline of Psychiatry, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Krystal JH; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA., Lanius R; Department of Psychiatry, Western University, London, ON, Canada.; Department of Neuroscience, Western University, London, ON, Canada., Larson C; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Depression and Anxiety Disorders, McLean Hospital, Harvard University, Belmont, MA, USA., Levy I; Department of Psychology, Yale University, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA., Li G; Laboratory for Traumatic Stress Studies, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Liberzon I; Department of Psychiatry and Behavioral Science. Texas A&M University College of Medicine, College Station, TX, USA., Logue MW; National Center for PTSD: Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, USA.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Medicine: Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Magnotta VA; Department of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA., Manthey A; Health and Medical University Potsdam, Potsdam, Germany., Maron-Katz A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., May G; Department of Psychiatry and Behavioral Science. Texas A&M University College of Medicine, College Station, TX, USA.; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA., McLaughlin KA; Ballmer Institute for Children's Behavioral Health, University of Oregon, Portland, OR, USA.; Department of Psychology, Harvard University, Cambridge, MA, USA., Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Nawijn L; Department of Psychiatry, University of Amsterdam, Amsterdam, Netherlands.; Department of Clinical Psychology, Leiden University, Leiden, Netherlands., Nelson SM; Department of Pediatrics and Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA., Neria Y; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Neufeld RWJ; Department of Psychiatry, Western University, London, ON, Canada.; Department of Neuroscience, Western University, London, ON, Canada., Nitschke JB; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA., O'Leary EN; Department of Psychiatry, University of Toledo, Toledo, OH, USA., Olatunji BO; Department of Psychology, Vanderbilt University, Nashville, TN, USA., Olff M; Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; ARQ National Psychotrauma Centre, Diemen, Netherlands., Olson EA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA., Peverill M; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA., Phan KL; Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH, USA., Pineda E; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA., Ressler KJ; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Rosso IM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA., Salminen LE; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Meltzer K; Department of Radiology, University of Washington, Seattle, WA, USA., Schmahl C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Seedat S; South African Medical Research Council on the Genomics of Brain Disorders, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Sharp CA; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA., Shenton ME; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, MA, USA.; Massachusetts General Hospital, Boston, MA, USA., Sierk A; Department of Psychiatry and Psychotherapy, University Medical Centre Charité, Berlin, Germany., Simons RM; Department of Psychology, University of South Dakota, Vermillion, SD, USA., Simons JS; Sioux Falls VA Health Care System, Sioux Falls, SD, USA.; Department of Psychology, University of South Dakota, Vermillion, SD, USA., Sponheim SR; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.; Minneapolis VA Health Care System, Minneapolis, MN, USA., Stein MB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; School of Public Health, University of California San Diego, La Jolla, CA, USA., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Suarez-Jimenez B; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA., Théberge J; Department of Psychiatry, Western University, London, ON, Canada., Thomopolous SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.; Leiden Institute for Brain and Cognition, Leiden, Netherlands., van der Werff SJA; Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.; Leiden Institute for Brain and Cognition, Leiden, Netherlands., van Erp TGM; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA., van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., van Zuiden M; Department of Psychiatry, University of Amsterdam, Amsterdam, Netherlands.; Department of Clinical Psychology, Utrecht University, Utrecht, Netherlands., Veltman DJ; Department of Psychiatry, University of Amsterdam, Amsterdam, Netherlands., Vermeiren RRJM; Department of Psychiatry & Psychology, Leiden University Medical Center, Leiden, Netherlands., Walter H; Department of Psychiatry and Clinical Neuroscience, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Mental Health, Partner Site Berlin-Potsdam, Berlin, Germany., Wang X; Department of Neuroscience and Psychiatry, University of Toledo, Toledo, OH, USA., Wang L; Laboratory for Traumatic Stress Studies, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Xie H; Department of Neuroscience and Psychiatry, University of Toledo, Toledo, OH, USA., Zhu X; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA., Zhu Y; Laboratory for Traumatic Stress Studies, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Andreassen OA; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, Oslo University Hospital, Oslo, Norway., Stein DJ; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Morey RA; Brain Imaging Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA., Dalvie S; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; South African Medical Research Council Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-026-03718-w