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Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata.

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Title: Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata.
Authors: Steenbuck N; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, ETH Zurich and University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Damond N; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Engler S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Kusmartseva I; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Posgai AL; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Drotar DM; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Williams MD; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., de Souza N; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.; Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Brusko TM; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.; Department of Pediatrics, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Brusko MA; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Wasserfall CH; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Atkinson MA; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA. atkinson@pathology.ufl.edu.; Department of Pediatrics, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA. atkinson@pathology.ufl.edu., Bodenmiller B; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.
Source: Nature metabolism [Nat Metab] 2026 Jul; Vol. 8 (7), pp. 1603-1620. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Steenbuck+N%22">Steenbuck N</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, ETH Zurich and University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Damond+N%22">Damond N</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Engler+S%22">Engler S</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kusmartseva+I%22">Kusmartseva I</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Posgai+AL%22">Posgai AL</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Drotar+DM%22">Drotar DM</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Williams+MD%22">Williams MD</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22de+Souza+N%22">de Souza N</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.; Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brusko+TM%22">Brusko TM</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.; Department of Pediatrics, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brusko+MA%22">Brusko MA</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Wasserfall+CH%22">Wasserfall CH</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+MA%22">Atkinson MA</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA. atkinson@pathology.ufl.edu.; Department of Pediatrics, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA. atkinson@pathology.ufl.edu.<br /><searchLink fieldCode="AU" term="%22Bodenmiller+B%22">Bodenmiller B</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.
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