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OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation.

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Title: OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation.
Authors: Cao Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Zhu Z; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Zeng P; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Mei F; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Wang D; The First School of Medicine and School of Information and Engineering, Wenzhou Medical University, Wenzhou, China., Xu J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Xu Y; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Chen K; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Wei C; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Shen J; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Jin K; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Chen J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Li Z; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China., Liu B; Department of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Schlüter D; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany., Huang J; Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Wang X; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. sunrim@163.com.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China. sunrim@163.com.; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany. sunrim@163.com.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Cao+Z%22">Cao Z</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zeng+P%22">Zeng P</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Mei+F%22">Mei F</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; The First School of Medicine and School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+C%22">Wei C</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Jin+K%22">Jin K</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Department of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Schlüter+D%22">Schlüter D</searchLink>; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. sunrim@163.com.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, China. sunrim@163.com.; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany. sunrim@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s44321-026-00473-x
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        Text: English
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      – TitleFull: OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation.
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              Text: 2026 Jul 02
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