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Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.

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Title: Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.
Authors: Yen CJ; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. yencj@mail.ncku.edu.tw.; National Cheng Kung University Hospital Cancer Center, Tainan, Taiwan. yencj@mail.ncku.edu.tw., Chen MH; Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen YY; Hematology and Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Bai LY; Division of Hematology and Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen JS; Hematology-Oncology, Linkou Chang Gung Memorial Hospital & Chang Gung University, Taoyuan, Taiwan., Hsieh JC; Division of Hematology-Oncology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan., Shih YH; Hematology and Medical Oncology, Taichung Veterans General Hospital, Taichung, Taiwan., Wu IC; Gastroenterology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Chen YL; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan., Chen CM; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan., Chao TY; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan., Chu YW; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan., Chien DS; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan.
Source: British journal of cancer [Br J Cancer] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.
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  Data: <searchLink fieldCode="AU" term="%22Yen+CJ%22">Yen CJ</searchLink>; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. yencj@mail.ncku.edu.tw.; National Cheng Kung University Hospital Cancer Center, Tainan, Taiwan. yencj@mail.ncku.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+MH%22">Chen MH</searchLink>; Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Hematology and Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bai+LY%22">Bai LY</searchLink>; Division of Hematology and Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JS%22">Chen JS</searchLink>; Hematology-Oncology, Linkou Chang Gung Memorial Hospital & Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+JC%22">Hsieh JC</searchLink>; Division of Hematology-Oncology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+YH%22">Shih YH</searchLink>; Hematology and Medical Oncology, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+IC%22">Wu IC</searchLink>; Gastroenterology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YL%22">Chen YL</searchLink>; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CM%22">Chen CM</searchLink>; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+TY%22">Chao TY</searchLink>; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+YW%22">Chu YW</searchLink>; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+DS%22">Chien DS</searchLink>; TaiRx, Inc., Nankang Business Park, Taipei, Taiwan.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+on+behalf+of+Cancer+Research+UK%22">Nature Publishing Group on behalf of Cancer Research UK </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0370635 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1827 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200070920%22">00070920 </searchLink><i>NLM ISO Abbreviation: </i>Br J Cancer <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 02
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