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Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge.

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Title: Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge.
Authors: Kuo B; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Nam S; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA., Kaur V; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA., Jones F; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA., Mercader JM; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of Harvard and MIT, Cambridge, MA., Yee SW; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA., Florez JC; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Srinivasan S; Division of Pediatrics, University of California San Francisco, San Francisco, CA., Li JH; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE
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  Data: Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge.
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  Data: <searchLink fieldCode="AU" term="%22Kuo+B%22">Kuo B</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Nam+S%22">Nam S</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Kaur+V%22">Kaur V</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Jones+F%22">Jones F</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Mercader+JM%22">Mercader JM</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of Harvard and MIT, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Yee+SW%22">Yee SW</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Srinivasan+S%22">Srinivasan S</searchLink>; Division of Pediatrics, University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Li+JH%22">Li JH</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital Boston, MA.; Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
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        Value: 10.1210/clinem/dgag262
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        Text: English
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      – TitleFull: Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge.
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            – D: 03
              M: 07
              Text: 2026 Jul 03
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              Y: 2026
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