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Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells.

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Title: Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells.
Authors: Karbalayghareh A; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pelzer B; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.; Clinic for Hematology and Stem Cell Transplantation, University Hopsital Essen, Essen, 45147, Germany., Chin CR; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA., Melnick A; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA., Barisic D; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Karbalayghareh+A%22">Karbalayghareh A</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Pelzer+B%22">Pelzer B</searchLink>; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.; Clinic for Hematology and Stem Cell Transplantation, University Hopsital Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Chin+CR%22">Chin CR</searchLink>; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Melnick+A%22">Melnick A</searchLink>; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Barisic+D%22">Barisic D</searchLink>; Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jun 23. <i>Date of Electronic Publication: </i>2026 Jun 23.
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        Value: 10.1101/2025.04.24.650458
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        Text: English
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              Text: 2026 Jun 23
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