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Resolving the dilution paradox to improve the interpretation of extracellular vesicle biomarker studies.

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Title: Resolving the dilution paradox to improve the interpretation of extracellular vesicle biomarker studies.
Authors: Rops J; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands., Buntsma NC; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.; Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurovascular Disorders, Amsterdam, Netherlands., Gąsecka A; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Cardiology, Medical University of Warsaw, Warsaw, Poland., Nieuwland R; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, Netherlands., Rosiek A; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland., Roos YBWEM; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.; Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurovascular Disorders, Amsterdam, Netherlands., Nossent AY; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Kruyt ND; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands., van der Pol E; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands., Eyileten C; Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Warsaw, Poland.; Genomics Core Facility, Center of New Technologies (CeNT), University of Warsaw, Warsaw, Poland.
Source: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2026 May 08; Vol. 10 (4), pp. 106636. Date of Electronic Publication: 2026 May 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101703775 Publication Model: eCollection Cited Medium: Internet ISSN: 2475-0379 (Electronic) Linking ISSN: 24750379 NLM ISO Abbreviation: Res Pract Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rops+J%22">Rops J</searchLink>; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Buntsma+NC%22">Buntsma NC</searchLink>; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.; Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurovascular Disorders, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Gąsecka+A%22">Gąsecka A</searchLink>; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Nieuwland+R%22">Nieuwland R</searchLink>; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rosiek+A%22">Rosiek A</searchLink>; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Roos+YBWEM%22">Roos YBWEM</searchLink>; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.; Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience, Neurovascular Disorders, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Nossent+AY%22">Nossent AY</searchLink>; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kruyt+ND%22">Kruyt ND</searchLink>; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Pol+E%22">van der Pol E</searchLink>; Laboratory of Experimental Clinical Chemistry, Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Eyileten+C%22">Eyileten C</searchLink>; Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Warsaw, Poland.; Genomics Core Facility, Center of New Technologies (CeNT), University of Warsaw, Warsaw, Poland.
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  Data: <searchLink fieldCode="JN" term="%22101703775%22">Research and practice in thrombosis and haemostasis</searchLink> [Res Pract Thromb Haemost] 2026 May 08; Vol. 10 (4), pp. 106636. <i>Date of Electronic Publication: </i>2026 May 08 (<i>Print Publication: </i>2026).
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              Text: 2026 May 08
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