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Study protocol and statistical analysis plan for a randomized controlled trial evaluating the safety and feasibility of the recombinant human platelet-derived growth factor B (rhPDGF-BB)-enhanced collagen plug for complex perianal fistula healing.

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Title: Study protocol and statistical analysis plan for a randomized controlled trial evaluating the safety and feasibility of the recombinant human platelet-derived growth factor B (rhPDGF-BB)-enhanced collagen plug for complex perianal fistula healing.
Authors: Kuo MC, Younan SA, Lempicki MD, Hawkins AT, Smith J, Shirey-Rice JK, Pulley JM, Lynch SE, Ueland TE, Khan A, Clark CR, Blette BS
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42396268
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Study protocol and statistical analysis plan for a randomized controlled trial evaluating the safety and feasibility of the recombinant human platelet-derived growth factor B (rhPDGF-BB)-enhanced collagen plug for complex perianal fistula healing.
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  Data: <searchLink fieldCode="AU" term="%22Kuo+MC%22">Kuo MC</searchLink><br /><searchLink fieldCode="AU" term="%22Younan+SA%22">Younan SA</searchLink><br /><searchLink fieldCode="AU" term="%22Lempicki+MD%22">Lempicki MD</searchLink><br /><searchLink fieldCode="AU" term="%22Hawkins+AT%22">Hawkins AT</searchLink><br /><searchLink fieldCode="AU" term="%22Smith+J%22">Smith J</searchLink><br /><searchLink fieldCode="AU" term="%22Shirey-Rice+JK%22">Shirey-Rice JK</searchLink><br /><searchLink fieldCode="AU" term="%22Pulley+JM%22">Pulley JM</searchLink><br /><searchLink fieldCode="AU" term="%22Lynch+SE%22">Lynch SE</searchLink><br /><searchLink fieldCode="AU" term="%22Ueland+TE%22">Ueland TE</searchLink><br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink><br /><searchLink fieldCode="AU" term="%22Clark+CR%22">Clark CR</searchLink><br /><searchLink fieldCode="AU" term="%22Blette+BS%22">Blette BS</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Jun 24. <i>Date of Electronic Publication: </i>2026 Jun 24.
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  Data: Journal Article; Preprint
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42396268
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.64898/2026.06.22.26356267
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: Study protocol and statistical analysis plan for a randomized controlled trial evaluating the safety and feasibility of the recombinant human platelet-derived growth factor B (rhPDGF-BB)-enhanced collagen plug for complex perianal fistula healing.
        Type: main
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            NameFull: Kuo MC
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            NameFull: Younan SA
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            NameFull: Lempicki MD
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            NameFull: Hawkins AT
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            NameFull: Smith J
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            NameFull: Shirey-Rice JK
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            NameFull: Clark CR
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            NameFull: Blette BS
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          Dates:
            – D: 24
              M: 06
              Text: 2026 Jun 24
              Type: published
              Y: 2026
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
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