Pembrolizumab, Temozolomide and HSPPC-96 Vaccine in Newly Diagnosed Glioblastoma Post-Chemoradiation: Results from a Multi-institutional, Phase 2, Randomized, Placebo-Controlled Trial.
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| Title: | Pembrolizumab, Temozolomide and HSPPC-96 Vaccine in Newly Diagnosed Glioblastoma Post-Chemoradiation: Results from a Multi-institutional, Phase 2, Randomized, Placebo-Controlled Trial. |
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| Authors: | Ozer BH; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Lindhorst SM; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Merrell RT; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Trevino CR; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Rudnick JD; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Avgeropoulos NG; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Ramakrishna N; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Khagi S; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Rauf Y; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Walbert T; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Pan E; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Youssef M; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Fink KL; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Mandel JJ; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Taylor LP; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Colman H; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Dunbar EM; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Paleologos N; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Burton EC; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Wu J; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Leeper HE; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Gonzalez J; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Penas-Prado M; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Raizer JJ; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Veglia E; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Craig S; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Yuan Y; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Chambers C; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Wall K; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Grajkowska E; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Mendoza T; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Armstrong TS; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.)., Gilbert MR; Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, Maryland, USA (B.H.O., E.B., J.W., H.L., J.G., M.P.-P., Y.Y., C.C., K.W., E.G., T.M., T.S.A., M.R.G.); Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA (S.M.L.); Department of Neurology, NorthShore University Health System, Chicago, Illinois, USA (R.T.M., C.R.T.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA (J.D.R.); Department of Hematology and Medical Oncology (N.G.A.) and Department of Radiation Oncology (N.R.), Orlando Regional Medical Center, Orlando, Florida, USA (N.G.A., N.R.); Department of Neurology and Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S.K., Y.R.); Department of Neurology and Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA (T.W.); Department of Neurology, University of Texas Southwestern, Dallas, Texas, USA (E.P., M.Y.); Department of Neurology/Neuro-Oncology, Baylor Scott&White, Baylor University Medical Center, Houston, Texas, USA (K.L.F.); Department of Neurology, Baylor College of Medicine, Houston, Texas, USA (J.J.M.); Department of Neurology, Alvord Brain Tumor Center, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA (L.P.T.); Department of Neurosurgery, Huntsman Cancer Institute, Salt Lake City, Utah, USA (H.C.); Piedmont Brain Tumor Center, Atlanta, Georgia, USA (E.M.D.); Division of Neurology, Advocate Medical Group, Downers Grove, Illinois, USA (N.P.); Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (J.J.R.); Department of Biostatistics, MD Anderson Cancer Center, Houston, Texas, USA (Y.Y.); Scientific Leadership and Research Manager, MSD/Merck&Co, Inc., Rahway, New Jersey, USA (E.V.); Director of Manufacturing and Logistics, Agenus, Lexington, Massachusetts, USA (S.C.). |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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