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Combinatorial Targeting of Avapritinib-Driven MAP Kinase Activation in High-Grade Glioma.

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Title: Combinatorial Targeting of Avapritinib-Driven MAP Kinase Activation in High-Grade Glioma.
Authors: Schwark K; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Wink K; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., De Cola A; Ludwig Institute for Cancer Research; Oxford, United Kingdom., Miclea M; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Patel T; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Kong S; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Stanczak A; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Doherty R; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Pearson A; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Murthy B; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Lau B; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Cartaxo RT; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Messinger D; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Ji S; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Wadden J; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Clausen M; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., de la Nava D; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Goethe P; Department of Neurosurgery, University of Michigan; Ann Arbor, MI, 48109, USA., Momen F; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Adam T; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Hutchinson A; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Niculcea M; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Serhan H; Department of Internal Medicine, University of Michigan; Ann Arbor, MI, USA., Merrill NM; Department of Internal Medicine, University of Michigan; Ann Arbor, MI, USA., Edmonds A; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Mayr L; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna; Vienna, Austria., Neyazi S; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School; Boston, MA, USA., Muñoz DP; Department of Radiation Oncology, University of California San Francisco; San Francisco, CA, USA., Hwang Y; Department of Radiation Oncology, University of California San Francisco; San Francisco, CA, USA., Nuechterlein NK; Department of Pathology, University of Michigan; Ann Arbor, MI, USA., Fernández EC; Department of Systems Biology, Columbia University; New York, NY, USA., Califano A; Department of Systems Biology, Columbia University; New York, NY, USA., Pavisic J; Department of Pediatrics, Columbia University; New York, NY, USA., Garton H; Department of Neurosurgery, University of Michigan; Ann Arbor, MI, 48109, USA., Rao R; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Upadhyaya SA; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA., Skrypek M; Department of Pediatric Hematology-Oncology, Children's Minnesota; Minneapolis, MN, USA., Bendel AE; Department of Pediatric Hematology-Oncology, Children's Minnesota; Minneapolis, MN, USA., Lobbous M; Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University; Cleveland, OH, USA., Klawinski D; Department of Pediatrics, Nemours Children's Health System; Jacksonville, FL, USA., Merajver SD; Department of Internal Medicine, University of Michigan; Ann Arbor, MI, USA., Koptyra MP; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia; Philadelphia, PA, USA., Resnick AC; Department of Surgery, Children's Hospital of Philadelphia; Philadelphia, PA, USA., Nazarian J; Department of Pediatrics, University Children's Hospital, University of Zurich, Zurich, Switzerland., Venneti S; Department of Pathology, University of Michigan; Ann Arbor, MI, USA., Waszak SM; School of Life Sciences, École Polytechnique Fédérale de Lausanne; Lausanne, Switzerland., Chavez L; Department of Medicine, University of California San Diego; La Jolla, CA, USA., Gojo J; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna; Vienna, Austria., Filbin MG; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School; Boston, MA, USA., Beck A; Center for Neuropathology, Ludwig Maximillian University of Munich; Munich, Germany., Pathania M; Ludwig Institute for Cancer Research; Oxford, United Kingdom., Coppe JF; Department of Radiation Oncology, University of California San Francisco; San Francisco, CA, USA., Koschmann C; Department of Pediatrics, University of Michigan; Ann Arbor, MI, USA.
Source: Research square [Res Sq] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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