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A Novel Dosing Strategy for Tacrolimus in Lung Transplant Recipients: Integrating Machine Learning with Population Pharmacokinetic Analysis.

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Title: A Novel Dosing Strategy for Tacrolimus in Lung Transplant Recipients: Integrating Machine Learning with Population Pharmacokinetic Analysis.
Authors: Cai XJ; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida., Li ZR; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California., Chen Y; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China., Yang H; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Huang Y; Department of Pharmacy, Wuxi Medical Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Lu YR; Department of Pharmacy, Wuxi Medical Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Zhou WB; Department of Pharmacy, Wuxi Medical Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Shi LZ; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Fan L; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Chen JY; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and., Lu PH; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Wu B; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Source: Therapeutic drug monitoring [Ther Drug Monit] 2026 Jul 06. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7909660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-3694 (Electronic) Linking ISSN: 01634356 NLM ISO Abbreviation: Ther Drug Monit Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Cai+XJ%22">Cai XJ</searchLink>; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Li+ZR%22">Li ZR</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Pharmacy, Wuxi Medical Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Lu+YR%22">Lu YR</searchLink>; Department of Pharmacy, Wuxi Medical Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Zhou+WB%22">Zhou WB</searchLink>; Department of Pharmacy, Wuxi Medical Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.; Department of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.; Division of Pharmacy, Wuxi Higher Health Vocational Technology School, Wuxi, China.; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Shi+LZ%22">Shi LZ</searchLink>; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.; Center for Lung Transplantation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; and.<br /><searchLink fieldCode="AU" term="%22Lu+PH%22">Lu PH</searchLink>; Center of Clinical Research, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Lung Transplant Center, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1097/FTD.0000000000001495
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: A Novel Dosing Strategy for Tacrolimus in Lung Transplant Recipients: Integrating Machine Learning with Population Pharmacokinetic Analysis.
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            NameFull: Cai XJ
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            – D: 06
              M: 07
              Text: 2026 Jul 06
              Type: published
              Y: 2026
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