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Modulation of the ACLY-AMPK axis by bempedoic acid suppresses NF-κB-driven inflammation, VEGF-Notch angiogenic crosstalk, and cell-cycle progression in Solid Ehrlich Carcinoma.

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Title: Modulation of the ACLY-AMPK axis by bempedoic acid suppresses NF-κB-driven inflammation, VEGF-Notch angiogenic crosstalk, and cell-cycle progression in Solid Ehrlich Carcinoma.
Authors: Saleh A; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia., Raslan NA; Department of Clinical Pharmacy, Al-Rayan National College of Health Sciences, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia., Selim HMRM; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, 13713, Diriyah, Riyadh, Saudi Arabia.; Research Center, Deanship of Scientific Research and Post-Graduate Studies, AlMaarefa University, 13713, Diriyah, Riyadh, Saudi Arabia., Farghly AM; Department of Clinical Pharmacy, Al-Rayan National College of Health Sciences, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia., Ali SK; Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt., Galal O; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt., Barakat BM; Department of Clinical Pharmacy, Faculty of Pharmacy, Al Baha University, 1988, Al Baha, Saudi Arabia., Fayyad RM; Pharmacology Department, General Medicine Practice Program, Batterjee Medical College, 62451, Aseer, Saudi Arabia.; Pharmacology Department, Faculty of Medicine, Al-Azhar University, Nasr City, 11884, Cairo, Egypt., Rizk SH; Biochemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6Th of October City, Giza, Egypt., Elhusseiny SM; Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Badawy AI; Department of Clinical Nursing Sciences, Al-Rayan National College of Nursing, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia., Saadat HMF; Clinical Pharmacy Specialist, Pharm D Master, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Salem MA; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Salama A; Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia., Aboelsoud HA; Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.; Department of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Ali MHH; Department of Anatomy and Embryology, Faculty of Medicine, Al Azhar University, Assuit, Egypt., Abd Allatif AAA; Department of Anatomy and Embryology, Faculty of Medicine, Al Azhar University, Assuit, Egypt., Mohamed MFA; Department of Anatomy and Embryology, Faculty of Medicine, Al Azhar University, Assuit, Egypt., Hanafy SM; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Mohamed SM; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.; Department of Physiology, Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt., Elashrey AM; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Mousa SNM; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Soliman WI; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Motawei SM; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., El-Dessouki AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt. ahmed.desoky@acu.edu.eg.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: Modulation of the ACLY-AMPK axis by bempedoic acid suppresses NF-κB-driven inflammation, VEGF-Notch angiogenic crosstalk, and cell-cycle progression in Solid Ehrlich Carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Saleh+A%22">Saleh A</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Raslan+NA%22">Raslan NA</searchLink>; Department of Clinical Pharmacy, Al-Rayan National College of Health Sciences, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Selim+HMRM%22">Selim HMRM</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, 13713, Diriyah, Riyadh, Saudi Arabia.; Research Center, Deanship of Scientific Research and Post-Graduate Studies, AlMaarefa University, 13713, Diriyah, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Farghly+AM%22">Farghly AM</searchLink>; Department of Clinical Pharmacy, Al-Rayan National College of Health Sciences, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ali+SK%22">Ali SK</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.<br /><searchLink fieldCode="AU" term="%22Galal+O%22">Galal O</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Barakat+BM%22">Barakat BM</searchLink>; Department of Clinical Pharmacy, Faculty of Pharmacy, Al Baha University, 1988, Al Baha, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Fayyad+RM%22">Fayyad RM</searchLink>; Pharmacology Department, General Medicine Practice Program, Batterjee Medical College, 62451, Aseer, Saudi Arabia.; Pharmacology Department, Faculty of Medicine, Al-Azhar University, Nasr City, 11884, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Rizk+SH%22">Rizk SH</searchLink>; Biochemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6Th of October City, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Elhusseiny+SM%22">Elhusseiny SM</searchLink>; Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Badawy+AI%22">Badawy AI</searchLink>; Department of Clinical Nursing Sciences, Al-Rayan National College of Nursing, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Saadat+HMF%22">Saadat HMF</searchLink>; Clinical Pharmacy Specialist, Pharm D Master, Faculty of Pharmacy, Tanta University, Tanta, Egypt.<br /><searchLink fieldCode="AU" term="%22Salem+MA%22">Salem MA</searchLink>; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.<br /><searchLink fieldCode="AU" term="%22Salama+A%22">Salama A</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aboelsoud+HA%22">Aboelsoud HA</searchLink>; Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.; Department of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ali+MHH%22">Ali MHH</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Al Azhar University, Assuit, Egypt.<br /><searchLink fieldCode="AU" term="%22Abd+Allatif+AAA%22">Abd Allatif AAA</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Al Azhar University, Assuit, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+MFA%22">Mohamed MFA</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Al Azhar University, Assuit, Egypt.<br /><searchLink fieldCode="AU" term="%22Hanafy+SM%22">Hanafy SM</searchLink>; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+SM%22">Mohamed SM</searchLink>; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.; Department of Physiology, Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elashrey+AM%22">Elashrey AM</searchLink>; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Mousa+SNM%22">Mousa SNM</searchLink>; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Soliman+WI%22">Soliman WI</searchLink>; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Motawei+SM%22">Motawei SM</searchLink>; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Dessouki+AM%22">El-Dessouki AM</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt. ahmed.desoky@acu.edu.eg.
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