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G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells.

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Title: G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells.
Authors: Sharma AB; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.; Division of Cancer Biology, Council of Scientific & Industrial Research-Central Drug Research Institute, Lucknow, India., Krwawicz J; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK., Tappenden L; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK., Ramlee MK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore, Singapore., Abugable AA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK., Zhen X; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK., Khurana S; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Stracker TH; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Lakin ND; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK. nicholas.lakin@bioch.ox.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Sharma+AB%22">Sharma AB</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.; Division of Cancer Biology, Council of Scientific & Industrial Research-Central Drug Research Institute, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Krwawicz+J%22">Krwawicz J</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tappenden+L%22">Tappenden L</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ramlee+MK%22">Ramlee MK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Abugable+AA%22">Abugable AA</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zhen+X%22">Zhen X</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Khurana+S%22">Khurana S</searchLink>; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Stracker+TH%22">Stracker TH</searchLink>; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lakin+ND%22">Lakin ND</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK. nicholas.lakin@bioch.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jul 03. <i>Date of Electronic Publication: </i>2026 Jul 03.
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        Value: 10.1038/s41467-026-75083-9
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              Text: 2026 Jul 03
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