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Patient-derived resources for decoding and targeting brain metastases ecosystems.

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Title: Patient-derived resources for decoding and targeting brain metastases ecosystems.
Authors: Valiente M; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain. mvaliente@cnio.es., Aydoğan LE; Department of Hematology, Oncology, Hemostaseology, Stem Cell Transplantation, Medical Faculty, Center for Integrated Oncology (CIO) RWTH Aachen University, Aachen, Germany., Feigin N; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Gahn C; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Hernandez-Oliver C; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain., Milling F; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Oktem E; Biomedical Science and Engineering, Koç University, Istanbul, Türkiye., Ortega-Sabater C; CNIO Biobank, Spanish National Cancer Research Centre, Madrid, Spain., Priego N; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain., Ricci AA; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Capella G; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Mangherini L; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Serrano-Ron L; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Stammberger A; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Vazquez-Canto J; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain., Weber KJ; Goethe University Frankfurt, Neurological Institute (Edinger Institute), Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany., Wehner R; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Broggini T; Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany.; Department of Neurosurgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany., Czabanka M; Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany.; Department of Neurosurgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany., Aksu S; Biomedical Science and Engineering, Koç University, Istanbul, Türkiye., Al-Shahrour F; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Bertero L; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Schmitz M; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Tirosh I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Medyouf H; Department of Hematology, Oncology, Hemostaseology, Stem Cell Transplantation, Medical Faculty, Center for Integrated Oncology (CIO) RWTH Aachen University, Aachen, Germany. hmedyouf@ukaachen.de.
Corporate Authors: RISEBrain Consortium
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article; Review
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Valiente+M%22">Valiente M</searchLink>; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain. mvaliente@cnio.es.<br /><searchLink fieldCode="AU" term="%22Aydoğan+LE%22">Aydoğan LE</searchLink>; Department of Hematology, Oncology, Hemostaseology, Stem Cell Transplantation, Medical Faculty, Center for Integrated Oncology (CIO) RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Feigin+N%22">Feigin N</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Gahn+C%22">Gahn C</searchLink>; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Hernandez-Oliver+C%22">Hernandez-Oliver C</searchLink>; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Milling+F%22">Milling F</searchLink>; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Oktem+E%22">Oktem E</searchLink>; Biomedical Science and Engineering, Koç University, Istanbul, Türkiye.<br /><searchLink fieldCode="AU" term="%22Ortega-Sabater+C%22">Ortega-Sabater C</searchLink>; CNIO Biobank, Spanish National Cancer Research Centre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Priego+N%22">Priego N</searchLink>; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ricci+AA%22">Ricci AA</searchLink>; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Capella+G%22">Capella G</searchLink>; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Mangherini+L%22">Mangherini L</searchLink>; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Serrano-Ron+L%22">Serrano-Ron L</searchLink>; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Stammberger+A%22">Stammberger A</searchLink>; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Vazquez-Canto+J%22">Vazquez-Canto J</searchLink>; Brain Metastasis Group, Spanish National Cancer Research Centre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Weber+KJ%22">Weber KJ</searchLink>; Goethe University Frankfurt, Neurological Institute (Edinger Institute), Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Wehner+R%22">Wehner R</searchLink>; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Broggini+T%22">Broggini T</searchLink>; Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany.; Department of Neurosurgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Czabanka+M%22">Czabanka M</searchLink>; Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany.; Department of Neurosurgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Aksu+S%22">Aksu S</searchLink>; Biomedical Science and Engineering, Koç University, Istanbul, Türkiye.<br /><searchLink fieldCode="AU" term="%22Al-Shahrour+F%22">Al-Shahrour F</searchLink>; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bertero+L%22">Bertero L</searchLink>; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Schmitz+M%22">Schmitz M</searchLink>; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Tirosh+I%22">Tirosh I</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Medyouf+H%22">Medyouf H</searchLink>; Department of Hematology, Oncology, Hemostaseology, Stem Cell Transplantation, Medical Faculty, Center for Integrated Oncology (CIO) RWTH Aachen University, Aachen, Germany. hmedyouf@ukaachen.de.
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