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Identification of hub genes involved in early-onset schizophrenia: from genetic susceptibility to predicted regulated gene expression.

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Title: Identification of hub genes involved in early-onset schizophrenia: from genetic susceptibility to predicted regulated gene expression.
Authors: Jen Y; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Yu SL; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Hsiao PC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Kuo PH; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Liu CM; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Liu CC; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Hwang TJ; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.; Department of Psychiatry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan., Hsieh MH; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Chien YL; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Lin YT; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Huang H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Feng YA; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan., Hsiao CK; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan., Lin YF; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.; Department of Public Health & Medical Humanities, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Faraone SV; Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, and Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA., Neale B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Glatt SJ; Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, and Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA., Tsuang MT; Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Hwu HG; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan., Chen WJ; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. wjchen@nhri.edu.tw.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. wjchen@nhri.edu.tw.; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan. wjchen@nhri.edu.tw.; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan. wjchen@nhri.edu.tw.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: Identification of hub genes involved in early-onset schizophrenia: from genetic susceptibility to predicted regulated gene expression.
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  Data: <searchLink fieldCode="AU" term="%22Jen+Y%22">Jen Y</searchLink>; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+SL%22">Yu SL</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+PC%22">Hsiao PC</searchLink>; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+PH%22">Kuo PH</searchLink>; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CM%22">Liu CM</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CC%22">Liu CC</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hwang+TJ%22">Hwang TJ</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.; Department of Psychiatry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+MH%22">Hsieh MH</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+YL%22">Chien YL</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YT%22">Lin YT</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+YA%22">Feng YA</searchLink>; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+CK%22">Hsiao CK</searchLink>; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.; Department of Public Health & Medical Humanities, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Faraone+SV%22">Faraone SV</searchLink>; Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, and Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Neale+B%22">Neale B</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Glatt+SJ%22">Glatt SJ</searchLink>; Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, and Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tsuang+MT%22">Tsuang MT</searchLink>; Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hwu+HG%22">Hwu HG</searchLink>; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WJ%22">Chen WJ</searchLink>; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. wjchen@nhri.edu.tw.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. wjchen@nhri.edu.tw.; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan. wjchen@nhri.edu.tw.; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan. wjchen@nhri.edu.tw.
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        Value: 10.1038/s41380-026-03731-z
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              Text: 2026 Jul 03
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